CAJ | 학술논문

近年来,在急性髓系白血病(AML)中发现了多种染色体异常和基因突变并确定了其预后价值.提高对白血病生物学特点的认识有助于对其进行准确的诊断、预后分层以及监测微小残留病变,有利于开发靶向治疗药物和提高预后.文章就2013年美国血液学会年会上关于高危AML的染色体和基因突变特点以及临床试验中的新药研究现状进行综述.
근년래,재급성수계백혈병(AML)중발현료다충염색체이상화기인돌변병학정료기예후개치.제고대백혈병생물학특점적인식유조우대기진행준학적진단、예후분층이급감측미소잔류병변,유리우개발파향치료약물화제고예후.문장취2013년미국혈액학회년회상관우고위AML적염색체화기인돌변특점이급림상시험중적신약연구현상진행종술.
Acute myeloid leukemia (AML) is a group of heterogeneous diseases with diverse genetic abnormalities,variable responsiveness to therapy and prognosis.In recent years,a lot of information has become available regarding chromosome and gene mutations that occur in AML and their influence on prognosis.Improvements in the understanding of molecular biology of AML are critical for accurate diagnosis.risk stratification,monitoring of minimal residual disease and provides opportunities to develop targeted therapies and improve the clinical outcome.This article reviewed chromosome abnormalities and characteristic gene mutations,and discussed their clinical signiflcances and presented new drugs in clinical trials presented in the 55th ASH annual meeting.