新疆医科大学学报
新疆醫科大學學報
신강의과대학학보
JOURNAL OF XINJIANG MEDICAL UNIVERSITY
2014年
4期
444-449
,共6页
李婧%木胡牙提·乌拉斯汉%卢武红%刘志强%何鹏义%马尔加恩·巴克依
李婧%木鬍牙提·烏拉斯漢%盧武紅%劉誌彊%何鵬義%馬爾加恩·巴剋依
리청%목호아제·오랍사한%로무홍%류지강%하붕의%마이가은·파극의
心房颤动%VKORC1%基因多态性%民族差异%华法林
心房顫動%VKORC1%基因多態性%民族差異%華法林
심방전동%VKORC1%기인다태성%민족차이%화법림
atrial fibrillation%VKORC1%gene polymorphism%ethnic differences%warfarin
目的:探讨新疆地区哈萨克族、汉族心房颤动(atrial fibrillation ,AF)患者与维生素K环氧化物还原酶复合体亚单位1基因(vitamin K epoxide reductase complex subunit 1,VKORC1)1639 G> A 位点多态性的关系。方法以哈萨克族、汉族原发性心房颤动患者各100例作为病例组,以哈萨克族、汉族无心房颤动患者各100例作为对照组,从外周静脉血中提取基因组DNA ,应用多聚酶链反应-限制性内切酶长度片段多态性(PCR-RFLP)方法检测VKORC1基因1639 G>A 位点基因型及等位基因频率。结果哈萨克族病例组和对照组 VKORC1基因1639 G>A 位点基因型频率和等位基因频率比较差异有统计学意义( P <0.05)。汉族病例组与对照组VKORC1基因1639 G>A位点基因型频率和等位基因频率比较差异有统计学意义(P<0.05)。哈萨克族病例组和汉族病例组VKORC1基因1639 G>A 位点基因型频率和等位基因频率比较差异有统计学意义(P <0.05)。男性病例组与女性病例组VKORC1基因1639 G>A位点基因型频率和等位基因频率比较,差异无统计学意义(P>0.05)。结论 VKORC1基因1639 G>A位点在新疆地区哈萨克族、汉族心房颤动患者分布中存在民族差异。
目的:探討新疆地區哈薩剋族、漢族心房顫動(atrial fibrillation ,AF)患者與維生素K環氧化物還原酶複閤體亞單位1基因(vitamin K epoxide reductase complex subunit 1,VKORC1)1639 G> A 位點多態性的關繫。方法以哈薩剋族、漢族原髮性心房顫動患者各100例作為病例組,以哈薩剋族、漢族無心房顫動患者各100例作為對照組,從外週靜脈血中提取基因組DNA ,應用多聚酶鏈反應-限製性內切酶長度片段多態性(PCR-RFLP)方法檢測VKORC1基因1639 G>A 位點基因型及等位基因頻率。結果哈薩剋族病例組和對照組 VKORC1基因1639 G>A 位點基因型頻率和等位基因頻率比較差異有統計學意義( P <0.05)。漢族病例組與對照組VKORC1基因1639 G>A位點基因型頻率和等位基因頻率比較差異有統計學意義(P<0.05)。哈薩剋族病例組和漢族病例組VKORC1基因1639 G>A 位點基因型頻率和等位基因頻率比較差異有統計學意義(P <0.05)。男性病例組與女性病例組VKORC1基因1639 G>A位點基因型頻率和等位基因頻率比較,差異無統計學意義(P>0.05)。結論 VKORC1基因1639 G>A位點在新疆地區哈薩剋族、漢族心房顫動患者分佈中存在民族差異。
목적:탐토신강지구합살극족、한족심방전동(atrial fibrillation ,AF)환자여유생소K배양화물환원매복합체아단위1기인(vitamin K epoxide reductase complex subunit 1,VKORC1)1639 G> A 위점다태성적관계。방법이합살극족、한족원발성심방전동환자각100례작위병례조,이합살극족、한족무심방전동환자각100례작위대조조,종외주정맥혈중제취기인조DNA ,응용다취매련반응-한제성내절매장도편단다태성(PCR-RFLP)방법검측VKORC1기인1639 G>A 위점기인형급등위기인빈솔。결과합살극족병례조화대조조 VKORC1기인1639 G>A 위점기인형빈솔화등위기인빈솔비교차이유통계학의의( P <0.05)。한족병례조여대조조VKORC1기인1639 G>A위점기인형빈솔화등위기인빈솔비교차이유통계학의의(P<0.05)。합살극족병례조화한족병례조VKORC1기인1639 G>A 위점기인형빈솔화등위기인빈솔비교차이유통계학의의(P <0.05)。남성병례조여녀성병례조VKORC1기인1639 G>A위점기인형빈솔화등위기인빈솔비교,차이무통계학의의(P>0.05)。결론 VKORC1기인1639 G>A위점재신강지구합살극족、한족심방전동환자분포중존재민족차이。
Objective To investigate the association between VKORC1 gene 1639 G>A polymorphism and Atrial Fibrillation in Xinjiang Kazaks and Hans′ patients .Methods Genetic DNA of peripheral venous blood was extracted from 200 primary Atrial Fibrillation patients including 100 patients from Kazakh and 100 from Han Ethnic group and 200 controls including 100 from Kazakh and 100 from Han Ethnic group . The 1639 G> A polymorphism of VKORC1 gene was detected by polymerase chain reaction (PCR) ,and the VKORC1 gene 1639 G> A polymorphism of Chymase gene was detected using PCR restriction frag-ment length polymorphism (RFLP) .Results There was difference between Kazakh AF group and Kazakh control group in VKORC1 Gene 1639 G> A polymorphism genotype frequency and allele frequency (P <0 .05) .There was also difference between Han AF group and Han control group in VKORC1 gene 1639 G>A polymorphism genotype frequency and allele frequency (P<0 .05) .There was difference between Ka-zakh Ethnic and Han Ethnic in VKORC1 Gene 1639 G> A polymorphic loci (P < 0 .05) .There was no difference between male AF and female AF in VKORC1 gene 1639 G>A polymorphism genotype frequen-cy and allele frequency (P > 0 .05) .Conclusions There is ethnic difference between Kazakh and Han in VKORC1 gene 1639 G>A polymorphic site .