CAJ | 학술논문

目的：探讨核黄素转运蛋白（RFT2）在维吾尔族妇女宫颈癌中的表达及临床意义。方法收集维吾尔族妇女宫颈癌患者癌组织标本及癌旁组织的正常宫颈黏膜石蜡包埋组织标本各30例；利用免疫组织化学方法检测宫颈癌组织标本及癌旁组织标本中RFT2表达水平。结果宫颈癌组织中RFT2表达水平为93．3％，其中强阳性、中度阳性、弱阳性、阴性表达率分别为40％、37％、17％、7％，癌旁组织中强阳性、中度阳性、弱阳性、阴性表达率分别为14％、27％、33％、27％。宫颈癌及癌旁组织中RFT2表达差异有统计学意义（P ＜0．05）。RFT2阳性表达与临床分期、淋巴结转移情况无关（P ＞0．05）。结论 RFT2高表达可能对维吾尔族妇女宫颈癌发生起促进作用。
목적：탐토핵황소전운단백（RFT2）재유오이족부녀궁경암중적표체급림상의의。방법수집유오이족부녀궁경암환자암조직표본급암방조직적정상궁경점막석사포매조직표본각30례；이용면역조직화학방법검측궁경암조직표본급암방조직표본중RFT2표체수평。결과궁경암조직중RFT2표체수평위93．3％，기중강양성、중도양성、약양성、음성표체솔분별위40％、37％、17％、7％，암방조직중강양성、중도양성、약양성、음성표체솔분별위14％、27％、33％、27％。궁경암급암방조직중RFT2표체차이유통계학의의（P ＜0．05）。RFT2양성표체여림상분기、림파결전이정황무관（P ＞0．05）。결론 RFT2고표체가능대유오이족부녀궁경암발생기촉진작용。
Objective To investigate the expression of riboflavin transporter RFT2 in cervical cancer and to analyze its clinical significance in Uighur women .Methods A total of 30 formalin-fixed ,paraffin-embed-ded CC samples were collected from department of gynaecology of the First Affiliated Hospital ,Medical University of Xinjiang ,China .The RFT2 protein expression were detected by using immune histo chemis-try (IHC) .Results Tumor tissues exhibited high RFT2 protein expression (7% ,17% ,37% and 40% for no RFT2 staining ,weak staining ,medium staining and strong staining ,respectively) ,which was signifi-cantly higher than that in the normal mucous membrane (27% ,33% ,27% and 14% for no RFT2 stai-ning ,weak staining ,medium staining and strong staining ,respectively :P <0 .05) ,the RFT2 protein ex-pression was not correlated with clinical stage ,lymph node metastasis (P>0 .05) .Conclusion This study suggested that the occurrence and development of cervical cancer in Uighur women was closely related to the high riboflavin protein expression level of RFT2 ,we can hypothesize that the over expression of RFT2 protein might plays an accelerative role in the genesis of cervical cancer in Uighur women .