CAJ | 학술논문

神经生长因子是作用于神经系统最重要的生物活性蛋白之一，在眼科临床中应用广泛，给药途径包括全身给药及局部给药。局部给药具有目标性，相对全身给药能更有效的达到必要的眼部浓度且减少了发生副作用的风险，已成为眼科疾病的常见治疗方法。随着给药途径的不断发展，相应的药代动力学研究也受到关注。本综述研究为神经生长因子在眼科局部给药和药代动力学研究提供参考。
신경생장인자시작용우신경계통최중요적생물활성단백지일，재안과림상중응용엄범，급약도경포괄전신급약급국부급약。국부급약구유목표성，상대전신급약능경유효적체도필요적안부농도차감소료발생부작용적풍험，이성위안과질병적상견치료방법。수착급약도경적불단발전，상응적약대동역학연구야수도관주。본종술연구위신경생장인자재안과국부급약화약대동역학연구제공삼고。
Nerve growth factor ( NGF ) is one of the most important active protein acting on the nervous system, it is applicated widely in ophthalmology, the administration route includes systemic drug administration and local drug administration. Compared to systemic drug administration, local drug administration is targeted, it is more effective to achieve the necessary concentration in eyes and it reduces the risk of side effects.Local drug administration has been a common treatment method in eye diseases. With the development of administration route, corresponding pharmacokinetic researches have received the concern.This review provides a reference for the study on ophthalmological administration routes and pharmacokinetics of nerve growth factor.