CAJ | 학술논문

干扰素是一种具有广泛生物活性的细胞因子，具有多方面的抗肿瘤作用。干扰素家族包括Ⅰ、Ⅱ、Ⅲ3种类型。研究表明，Ⅰ型干扰素尤其是INF-α2b联合单药氟尿嘧啶（5-FU）或以其为基础的化疗方案对胆系肿瘤有效，联合HELF方案（羟基喜树碱＋足叶乙甙＋亚叶酸钙＋5-FU）对晚期胆囊癌疗效较好；Ⅱ型干扰素除有较好的免疫调节作用外，可有效抑制胆系肿瘤细胞生长和促进细胞凋亡，在与钙调素（ CaM）拮抗剂、米非司酮及中药等联合运用时可增效；Ⅲ型干扰素目前仅用于病毒性疾病的治疗，但基础研究证实其抗肿瘤作用明确，值得进一步研究。本文就干扰素在胆系肿瘤治疗中的作用及其研究进展作一综述。
간우소시일충구유엄범생물활성적세포인자，구유다방면적항종류작용。간우소가족포괄Ⅰ、Ⅱ、Ⅲ3충류형。연구표명，Ⅰ형간우소우기시INF-α2b연합단약불뇨밀정（5-FU）혹이기위기출적화료방안대담계종류유효，연합HELF방안（간기희수감＋족협을대＋아협산개＋5-FU）대만기담낭암료효교호；Ⅱ형간우소제유교호적면역조절작용외，가유효억제담계종류세포생장화촉진세포조망，재여개조소（ CaM）길항제、미비사동급중약등연합운용시가증효；Ⅲ형간우소목전부용우병독성질병적치료，단기출연구증실기항종류작용명학，치득진일보연구。본문취간우소재담계종류치료중적작용급기연구진전작일종술。
Interferon is a kind of cytokines with broad biological activity, it has a wide range of anti-tumor effect. Interferon family includes three types, type Ⅰ, typeⅡ and typeⅢ. Studies have shown that typeⅠ interferon especially INF-α2b which com-bined with 5-FU-based chemotherapy can play a certain role in biliary tract cancer,and INF-αcombined with HELF chemotherapy regi-men is a nice regimen for advcanced gallbladder carcinoma.In addition to better immunomodulatory effects, type Ⅱ interferon can in-hibit biliary tumor cell and promote apoptosis.When typeⅡinterferon combined with CaM-antagonist or Mifeptistone or Chinese medi-cine can be synergistic. Type Ⅲ interferons currently uses only for the treatment of viral diseases, but basic researches clearly demon-strate its anti-tumor effect, it is worth further study. This article reveiws the progression of intereron in treating biliary tract cancer.