CAJ | 학술논문

目的：评估早期子宫内膜癌患者行保留生育功能治疗的临床疗效。方法回顾性分析南方医院2005年至2011年接受保留生育功能治疗的16例早期子宫内膜癌患者的临床及随访资料。孕激素受体（ PR）阳性患者每日口服160mg醋酸甲地孕酮，若治疗效果不佳，排除疾病进展后短期联用30mg他莫昔芬或GnRHα，PR阴性者联用60mg枸橼酸托瑞米芬治疗。结果16例患者平均治疗时间为8个月（5～14个月），获缓解11例（69％）；平均随访时间为50个月（12～70个月），复发1例（9％），自然妊娠3例，成功分娩2例。结论早期子宫内膜癌患者可以行保留生育功能治疗，安全可行且有效，但需要严格筛选适合人群并密切随访。
목적：평고조기자궁내막암환자행보류생육공능치료적림상료효。방법회고성분석남방의원2005년지2011년접수보류생육공능치료적16례조기자궁내막암환자적림상급수방자료。잉격소수체（ PR）양성환자매일구복160mg작산갑지잉동，약치료효과불가，배제질병진전후단기련용30mg타막석분혹GnRHα，PR음성자련용60mg구연산탁서미분치료。결과16례환자평균치료시간위8개월（5～14개월），획완해11례（69％）；평균수방시간위50개월（12～70개월），복발1례（9％），자연임신3례，성공분면2례。결론조기자궁내막암환자가이행보류생육공능치료，안전가행차유효，단수요엄격사선괄합인군병밀절수방。
Objective To evaluate the long-term oncologic and reproductive outcomes of fertility-preservation therapy for young women with stage I endometrial carcinoma( EC) who wanted to preserve fertility. Methods The oncologic and reproductive out-comes of 16 young patients with stage I endometrial cancer treated with fertility-preservation therapy from 2005 to 2011 in Nan Fang hospital was retrospectively analyzed. The patients with positive progesterone receptor ( PR) were given megestrolacetate ( MA) orally at 160mg/day. Excluding the progress of the disease, patients with poor effect were additionally given tamoxifen( TAM) orally at 30mg/day or GnRHα. Patients with negetive PR were additionally given toremifene( TRM) at 60mg/day. Results In this research, 11 of 16 patients showed a response ( 69%) , recurrence time was 8 months ( range 5-14) . After a median follow-up time of 58 months ( range 24-108) , all patients were survival, 1 patient experienced progression of disease. Three patients succeeded in pregnancy, and 2 born babies. Conclusion Fertility-preservation therapy for young women with stage I endometrial carcinoma was safe and highly effective. However, definitive admission and close surveillance need more attention.