环球中医药
環毬中醫藥
배구중의약
GLOBAL TCM
2014年
4期
300-304
,共5页
淫羊藿苷%神经保护作用%抗氧化%炎症因子
淫羊藿苷%神經保護作用%抗氧化%炎癥因子
음양곽감%신경보호작용%항양화%염증인자
Icariin%Neuroprotective effects%Antioxidant%Cytokine
淫羊藿苷是中药淫羊藿的主要活性成分,具有抗肿瘤、增强免疫、改善心脑血管、调节内分泌等多重药理学作用。近年来关于淫羊藿苷对中枢神经系统保护作用的研究日益增多,为了进一步推进淫羊藿苷对于防治中枢神经系统疾病的研究,本文结合近十年国内外对其保护神经元细胞的研究报道,系统地总结和陈述了淫羊藿苷发挥保护神经作用的几个途径,主要包括抗氧化应激、抑制炎症反应、影响单胺类递质及氨基酸类神经递质的释放、增加神经营养作用等几个方面,以及探讨了淫羊藿苷发挥神经保护作用的信号转导机制,为进一步推进淫羊藿苷的研究作出理论支持。
淫羊藿苷是中藥淫羊藿的主要活性成分,具有抗腫瘤、增彊免疫、改善心腦血管、調節內分泌等多重藥理學作用。近年來關于淫羊藿苷對中樞神經繫統保護作用的研究日益增多,為瞭進一步推進淫羊藿苷對于防治中樞神經繫統疾病的研究,本文結閤近十年國內外對其保護神經元細胞的研究報道,繫統地總結和陳述瞭淫羊藿苷髮揮保護神經作用的幾箇途徑,主要包括抗氧化應激、抑製炎癥反應、影響單胺類遞質及氨基痠類神經遞質的釋放、增加神經營養作用等幾箇方麵,以及探討瞭淫羊藿苷髮揮神經保護作用的信號轉導機製,為進一步推進淫羊藿苷的研究作齣理論支持。
음양곽감시중약음양곽적주요활성성분,구유항종류、증강면역、개선심뇌혈관、조절내분비등다중약이학작용。근년래관우음양곽감대중추신경계통보호작용적연구일익증다,위료진일보추진음양곽감대우방치중추신경계통질병적연구,본문결합근십년국내외대기보호신경원세포적연구보도,계통지총결화진술료음양곽감발휘보호신경작용적궤개도경,주요포괄항양화응격、억제염증반응、영향단알류체질급안기산류신경체질적석방、증가신경영양작용등궤개방면,이급탐토료음양곽감발휘신경보호작용적신호전도궤제,위진일보추진음양곽감적연구작출이론지지。
Icariin is one of the most dynamic composition of Epimedium, which has pharmacologi-cal functions of inhibiting tumor, enhancing immunity, improving heart and cerebral vessels, and regulating endocrine function. In recent years,researches on neuroprotective effects of icariin in central nervous sys-tem have been increased . To further promote the researches on prevention and cure on central nervous sys-tem diseases,this review systematically summarizes the neuroprotective effects of icariin on neurons inclu-ding the mechanism combined with research reports of Icariin at home and abroad, which include the fol-lowing, antioxigenic stess, inhibiting the inflammatory response, adjusting the release of neurotransmitter of monoamines and amino acids, and increasing neurotrophic effect. The signal transduction mechanism of icariin’s neuroprotective effect is also discussed, which may provide useful theoretical support to the re-search of icariin.