CAJ | 학술논문

目的：探讨交通心肾法中药对老龄雌性大鼠性激素水平的影响。方法选用15月龄雌性SD大鼠,将其分为空白组、中药治疗组、西药对照组和中药对照组,分别给予生理盐水、宁更丹、戊酸雌二醇和更年安灌胃,另选3月龄大鼠作为青年对照组。采用放射免疫法检测大鼠促卵泡刺激素( follicle stimulating hormone,FSH)、促黄体生成素( luteinizing hormone,LH)、雌二醇( estradiol, E2)。结果与空白组比较,中药治疗组雌激素明显升高,有显著性差异(P<0．05),且与西药对照组结果类似。中药对照组雌激素水平略有升高,但与空白组相比无显著性差异。中药治疗组、西药对照组、中药对照组FSH均有降低,与空白组均有显著性差异(P<0．05),但是西药对照组下降更为显著。结论交通心肾法可以升高老龄雌性大鼠雌激素,降低FSH水平,可能是其治疗更年期综合征的作用机制之一。
목적：탐토교통심신법중약대노령자성대서성격소수평적영향。방법선용15월령자성SD대서,장기분위공백조、중약치료조、서약대조조화중약대조조,분별급여생리염수、저경단、무산자이순화경년안관위,령선3월령대서작위청년대조조。채용방사면역법검측대서촉란포자격소( follicle stimulating hormone,FSH)、촉황체생성소( luteinizing hormone,LH)、자이순( estradiol, E2)。결과여공백조비교,중약치료조자격소명현승고,유현저성차이(P<0．05),차여서약대조조결과유사。중약대조조자격소수평략유승고,단여공백조상비무현저성차이。중약치료조、서약대조조、중약대조조FSH균유강저,여공백조균유현저성차이(P<0．05),단시서약대조조하강경위현저。결론교통심신법가이승고노령자성대서자격소,강저FSH수평,가능시기치료경년기종합정적작용궤제지일。
Objective Study the Method of promoting heart-kidney interaction herbs on influen-cing the sex hormone levels in old female rats. Methods Choose female SD rats aged 15 months. They were divided into blank group , Chinese medicine treatment group, western medicine control group, Chinese medicine control group , and they were given normal saline, Ning Gengdan, progynova and Gengnian’an gavage treatment respectively, Another 3 months old rats were chosen as the young control group. Methods Radioimmunoassay was used to measure the levels of follicular stimulating hormone ( FSH) , luteinizing hormone ( LH) , estradiol ( E2 ) . Results Compared with the blank group, Groups treated by Chinese herbs in rats with estrogen levels were markedly elevated, which have significant difference between two groups (P<0. 05) . The western medicine control group have similar results. Traditional Chinese medi-cine control group slightly elevated levels of estrogen, but there was no significant difference compared with the blank group. Chinese medicine treatment group, western medicine control group, and Chinese medicine control group rats FSH levels were decreased, which have significant difference compared with the blank group(P<0. 05), but the comparison group decreased more significantly. Conclusion Method of promo-ting heart-kidney interaction can increase the estrogen in aged female rats, decrease the level of FSH, which may be one of the mechanisms of the treatment of menopausal syndrome.