CAJ | 학술논문

目的：研究中药白疕合剂对银屑病样动物模型表皮细胞增殖及微血管的影响。方法用盐酸普萘洛尔诱导银屑病动物模型。将实验动物按随机数字表法分组,即正常组、模型组、白疕合剂低、高剂量组、消银颗粒组,分别给予相应的药物进行动物实验。采用酶联免疫吸附测定法检测血清环磷酸腺苷( cyclic adenosine monophosphate,cAMP)、环磷酸鸟苷( cyclic guanosine monophos-phate,cGMP)的含量及血管内皮生长因子水平。结果中药白疕合剂组血清中 cAMP含量升高、cGMP含量降低、cAMP/cGMP比值升高,与模型组比较均有显著性差异(P<0．01)；血清血管内皮生长因子水平降低,与模型组比较均有显著性差异(P<0．05)。结论中药白疕合剂对银屑病的治疗可能与提高血清中cAMP含量、降低cGMP含量、调节cAMP/cGMP比值及降低血清血管内皮生长因子水平有关。
목적：연구중약백비합제대은설병양동물모형표피세포증식급미혈관적영향。방법용염산보내락이유도은설병동물모형。장실험동물안수궤수자표법분조,즉정상조、모형조、백비합제저、고제량조、소은과립조,분별급여상응적약물진행동물실험。채용매련면역흡부측정법검측혈청배린산선감( cyclic adenosine monophosphate,cAMP)、배린산조감( cyclic guanosine monophos-phate,cGMP)적함량급혈관내피생장인자수평。결과중약백비합제조혈청중 cAMP함량승고、cGMP함량강저、cAMP/cGMP비치승고,여모형조비교균유현저성차이(P<0．01)；혈청혈관내피생장인자수평강저,여모형조비교균유현저성차이(P<0．05)。결론중약백비합제대은설병적치료가능여제고혈청중cAMP함량、강저cGMP함량、조절cAMP/cGMP비치급강저혈청혈관내피생장인자수평유관。
Objective To study the effect of white mange medicine mixture on the psoriasis-like epidermal cells proliferation function and microvascular of animal-model. Methods Propranolol was ap-plied to make the psoriasis-like model of animal. The experimental animals were randomly divided into nor-mal group,model group,white mange (low-and-high dose) group, and Xiaoyin granules(low-and high-dose)group, and then they were given corresponding medicine to carry on the experimentation. The level of cAMP and cGMP and serum vascular endothelial growth factor was detected by ELISA. Results The level of serum cAMP was increased and cGMP was decreased,the ratio of cAMP/cGMP was increased, which are of remarkable differences from the model group(P<0. 01). The level of serum VEGA was decreased re-markable differences from the model group ( P<0. 05 ) . Conclusion Chinese medical white mange pos-sesses the significant treatment effect on psoriasis, which maybe attributed to increase the level of serum cAMP and decrease the level of cGMP,adjust the ratio of cAMP/cGMP,and decrease the level of serum vascular endothelial growth factor.