检验医学与临床
檢驗醫學與臨床
검험의학여림상
JOURNAL OF LABORATORY MEDICINE AND CLINICAL SCIENCES
2014年
7期
875-876
,共2页
颈动脉粥样硬化%2型糖尿病%血浆同型半胱氨酸
頸動脈粥樣硬化%2型糖尿病%血漿同型半胱氨痠
경동맥죽양경화%2형당뇨병%혈장동형반광안산
carotid atherosclerosis%type 2 diabetes mellitus%plasma homocysteine
目的:2型糖尿病患者血浆同型半胱氨酸(Hcy )与颈动脉硬化的关系。方法将内蒙古自治区人民医院就诊的210例2型糖尿病患者纳入研究,对所有患者进行颈动脉超声分析测定其斑块积分,根据不同的斑块积分分成3组,记录3组患者的 Hcy、糖化血红蛋白(HbAlc)、空腹血糖(FGC)、餐后2 h血糖(2 h BG)、总胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、年龄之间的差异,并分析2型糖尿病患者发生颈动脉粥样硬化的危险因子。结果(1)3组患者 HbAlc、FGC、2 h BG、TC、HDL-C、LDL-C、年龄比较,差异均无统计学意义(P>0.05);(2)3组患者 Hcy浓度差异有统计学意义,随着颈动脉斑块积分增加浓度上调(P<0.05);(3)通过Lo-gistic分析方法可知 Hcy、HbAlc、FGC、2 h BG、TC、HDL-C、LDL-C、年龄均是颈动脉粥样硬化的危险因子。结论 H cy是导致动脉粥样硬化的独立危险因素之一,检测 H cy对颈动脉粥样硬化有一定的防治意义。
目的:2型糖尿病患者血漿同型半胱氨痠(Hcy )與頸動脈硬化的關繫。方法將內矇古自治區人民醫院就診的210例2型糖尿病患者納入研究,對所有患者進行頸動脈超聲分析測定其斑塊積分,根據不同的斑塊積分分成3組,記錄3組患者的 Hcy、糖化血紅蛋白(HbAlc)、空腹血糖(FGC)、餐後2 h血糖(2 h BG)、總膽固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、年齡之間的差異,併分析2型糖尿病患者髮生頸動脈粥樣硬化的危險因子。結果(1)3組患者 HbAlc、FGC、2 h BG、TC、HDL-C、LDL-C、年齡比較,差異均無統計學意義(P>0.05);(2)3組患者 Hcy濃度差異有統計學意義,隨著頸動脈斑塊積分增加濃度上調(P<0.05);(3)通過Lo-gistic分析方法可知 Hcy、HbAlc、FGC、2 h BG、TC、HDL-C、LDL-C、年齡均是頸動脈粥樣硬化的危險因子。結論 H cy是導緻動脈粥樣硬化的獨立危險因素之一,檢測 H cy對頸動脈粥樣硬化有一定的防治意義。
목적:2형당뇨병환자혈장동형반광안산(Hcy )여경동맥경화적관계。방법장내몽고자치구인민의원취진적210례2형당뇨병환자납입연구,대소유환자진행경동맥초성분석측정기반괴적분,근거불동적반괴적분분성3조,기록3조환자적 Hcy、당화혈홍단백(HbAlc)、공복혈당(FGC)、찬후2 h혈당(2 h BG)、총담고순(TC)、고밀도지단백(HDL-C)、저밀도지단백(LDL-C)、년령지간적차이,병분석2형당뇨병환자발생경동맥죽양경화적위험인자。결과(1)3조환자 HbAlc、FGC、2 h BG、TC、HDL-C、LDL-C、년령비교,차이균무통계학의의(P>0.05);(2)3조환자 Hcy농도차이유통계학의의,수착경동맥반괴적분증가농도상조(P<0.05);(3)통과Lo-gistic분석방법가지 Hcy、HbAlc、FGC、2 h BG、TC、HDL-C、LDL-C、년령균시경동맥죽양경화적위험인자。결론 H cy시도치동맥죽양경화적독립위험인소지일,검측 H cy대경동맥죽양경화유일정적방치의의。
Objective To discuss the relationship between plasma homocysteine (Hcy) and carotid atheroscle-rosis (CA) in patients with type 2 diabetes mellitus (T2DM) .Methods A total of 210 cases with T2DM in this hos-pital were enrolled and divided into three groups according to carotid plaque scores .Level of Hcy ,glycosylated hemo-globin A1c (HbAlc) ,fasting plasma glucose (FGC) ,2 h postprandial blood glucose level (2hBG) ,total cholesterol (TC) ,high-density lipoprotein-cholesterol (HDL-C) ,low density lipoprotein-cholesterol (LDL-c) and age were com-pared between the three groups .Wisk factors of carotid atherosclerosis in patients with T 2DM were analyzed .Results (1) There were no statistical differences of levels of HbAlc ,FGC ,2hBG ,TC ,HDL-C ,LDL-C and age between the three groups (P>0 .05) .(2) Hcy levels were with significant differences between the three groups ,and levels of Hcy increased with the increasing of carotid artery plaque scores (P<0 .05) .(3) Hcy ,HbAlc ,FGC ,2hBG ,TC ,HDL-C , LDL-C and age were all risk factors for carotid atherosclerosis ,as indicated by Logistic analysis .Conclusion Hcy could be an independent risk factor of atherosclerosis .Detection of HCY might be useful for the prevention and treat-ment of carotid atherosclerosis .