CAJ | 학술논문

目的：探讨血清中抗氧化型脂蛋白抗体（ALOA ）活性与缺血性脑卒中的相关性。方法分别检测45例缺血性脑卒中患者（男34例，女11例）和45例健康者（男23例，女22例）ALOA的活性及三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）。结果45例缺血性脑卒中患者，ALOA 活性阳性18例，阳性率为40．0％，45例健康对照患者，ALOA活性阳性4例，阳性率为8．9％，缺血性脑卒中组阳性率明显高于健康对照组，差异有统计学意义（P＜0．05）；缺血性脑卒中组TG、TC、LDL明显高于健康对照组，HDL明显低于健康对照组，差异均有统计学意义（P＜0．05）。结论缺血性脑卒中患者常伴有 ALOA活性升高，ALOA 活性与缺血性脑卒中发生、发展具有相关性。
목적：탐토혈청중항양화형지단백항체（ALOA ）활성여결혈성뇌졸중적상관성。방법분별검측45례결혈성뇌졸중환자（남34례，녀11례）화45례건강자（남23례，녀22례）ALOA적활성급삼선감유（TG）、총담고순（TC）、저밀도지단백（LDL）、고밀도지단백（HDL）。결과45례결혈성뇌졸중환자，ALOA 활성양성18례，양성솔위40．0％，45례건강대조환자，ALOA활성양성4례，양성솔위8．9％，결혈성뇌졸중조양성솔명현고우건강대조조，차이유통계학의의（P＜0．05）；결혈성뇌졸중조TG、TC、LDL명현고우건강대조조，HDL명현저우건강대조조，차이균유통계학의의（P＜0．05）。결론결혈성뇌졸중환자상반유 ALOA활성승고，ALOA 활성여결혈성뇌졸중발생、발전구유상관성。
Objective To investigate the correlation of activity of serum atherogenic lipid-oxidising antibodies (ALOA) in patients with cerebral ischemic stroke (CIS) .Methods The activity of serum ALOA ,and serum levels of triglyceride (TG) ,total cholesterol (TC) ,low density lipoprotein (LDL) and high density lipoprotein (HDL) were detected in 45 patients with CIS (CIS group) ,including 34 males and 11 females ,and 45 healthy subjects (control group) ,including 23 males and 22 females .Results In CIS group ,the positive rate of ALOA activity was 40 .0% (18/45) ,which was significantly higher than the 8 .9% (4/45) of control group (P<0 .05) .Serum levels of TG ,TC and LDL in CIS group were significantly higher than those of control group (P<0 .05) ,whereas serum HDL level in CIS group was significantly lower than that of control group (P<0 .05) .Conclusion Patients with CIS might be often accompanied by increased ALOA activity ,which could be correlated with the generation and development of CIS .