CAJ | 학술논문

目的：研究PTEN、P27和BAG-1在子宫内膜癌中的表达及其与临床病理特征的关系。方法免疫组织化学SP法检测东莞市太平人民医院102例子宫内膜癌组织、90例子宫内膜增生组织和44例正常子宫内膜组织PT EN、P27和BAG-1蛋白的表达并分析其临床意义。结果 PT EN和P27在子宫内膜癌及增生组织呈低表达，BAG-1呈高表达。PT EN和BAG-1表达与肿瘤的组织学分级及肌层浸润相关，BAG-1表达还与患者临床分期相关，而 P27表达与患者临床及病理特征均无明显相关性。三者关联性分析显示，PT EN与P27及BAG-1之间存在关联性，而P27与BAG-1之间无关联。结论子宫内膜癌及增生组织中PT EN和P27呈低表达，BAG-1呈高表达，三者在子宫内膜癌的发生发展中起一定的作用。
목적：연구PTEN、P27화BAG-1재자궁내막암중적표체급기여림상병리특정적관계。방법면역조직화학SP법검측동완시태평인민의원102례자궁내막암조직、90례자궁내막증생조직화44례정상자궁내막조직PT EN、P27화BAG-1단백적표체병분석기림상의의。결과 PT EN화P27재자궁내막암급증생조직정저표체，BAG-1정고표체。PT EN화BAG-1표체여종류적조직학분급급기층침윤상관，BAG-1표체환여환자림상분기상관，이 P27표체여환자림상급병리특정균무명현상관성。삼자관련성분석현시，PT EN여P27급BAG-1지간존재관련성，이P27여BAG-1지간무관련。결론자궁내막암급증생조직중PT EN화P27정저표체，BAG-1정고표체，삼자재자궁내막암적발생발전중기일정적작용。
Objective To stduy the expression of PTEN ,P27 and BAG-1 in endometrial carcinoma ,and to analysis the clinical significance .Methods The expression of PTEN ,P27 and BAG-1 in 102 cases of endometrial carcinoma ,90 cases of endometrial hy-perplasia and 44 cases of normal endometrium tissue were detected by immunohistochemistry .Results PTEN and P27 in endome-trial carcinoma and hyperplasia tissue showed lower expression ,BAG-1 showed high expression in them .The expression of PTEN and BAG-1 were well correlated to histology degree and muscular infiltration .BAG-1 expression also had a well correlated to clinical stage .In this study ,we had not find a correlated between the expression of P27 and clinical and pathology characteristic of patien . PTEN expression had a Pearson relevance to P27 or BAG-1 expression ,but there was no correlation between P27 and BAG-1 .Con-clusion PTEN and P27 in endometrial carcinoma and hyperplasia tissue showed lower expression ,BAG-1 showed high expression in them .PTEN ,P27 and BAG-1 might play a role in the development of endometrial cancer .