CAJ | 학술논문

目的：探讨急性脑梗死患者外周血CD133＋细胞的动态变化及其在评价脑梗死预后中的意义。方法采用流式细胞仪测定发病72 h以内的急性期脑梗死患者（梗死组80例）和有脑血管危险因素但无脑梗死发生的患者（对照组40例）外周血CD133＋细胞水平，并记录脑梗死患者入院时、3 d、7 d和14 d外周血CD133＋细胞水平和患者神经功能缺损评分（N I HSS评分）。结果急性梗死患者外周血 CD133＋细胞百分比低于对照组，差异有统计学意义（P＜0.05），且急性脑梗死患者外周血CD133＋数量逐渐上升，第7天达高峰，脑梗死患者第7天CD133＋细胞上升值与NI HSS评分改善值呈负相关（r＝-0.673，P＜0.05）。结论急性期脑梗死患者1周后外周血CD133＋细胞明显升高提示预后良好，CD133＋细胞对预测脑梗死预后具有一定意义。
목적：탐토급성뇌경사환자외주혈CD133＋세포적동태변화급기재평개뇌경사예후중적의의。방법채용류식세포의측정발병72 h이내적급성기뇌경사환자（경사조80례）화유뇌혈관위험인소단무뇌경사발생적환자（대조조40례）외주혈CD133＋세포수평，병기록뇌경사환자입원시、3 d、7 d화14 d외주혈CD133＋세포수평화환자신경공능결손평분（N I HSS평분）。결과급성경사환자외주혈 CD133＋세포백분비저우대조조，차이유통계학의의（P＜0.05），차급성뇌경사환자외주혈CD133＋수량축점상승，제7천체고봉，뇌경사환자제7천CD133＋세포상승치여NI HSS평분개선치정부상관（r＝-0.673，P＜0.05）。결론급성기뇌경사환자1주후외주혈CD133＋세포명현승고제시예후량호，CD133＋세포대예측뇌경사예후구유일정의의。
Objective To explore the dynamic changes and significance of the level of peripheral blood CD133 positive (CD133+ ) cells in patients with acute cerbral infarction.Methods The level of peripheral blood CD133+ cells was determined by flow cytometrywithin 72 hours of onset of patients with acute cerebral infarction (infarct group ,n= 80)and patients with cerebrovascular risk factors without cerebral infarction (control group ,n=40). The neural function deficit score were deter-mined in patients with infarction group.Results The percentage of peripheral blood CD133+ cells in infarction patients was lower than that in the control group ,the difference was statistically significant (P<0.05). And the increment of the level of percentage of CD133+cells in peripheral blood of patients was negatively correlated with the improvement in NIHSS score at day 7 (r= -0.673 ,P<0.05).Conclusion The increase of the level of percentage of CD133+cells in peripheral blood after acute ischemic stroke is associated with good functional outcome. And the level of percentage of CD133+cells in peripheral blood has certain significance in predicting cerebral infarction outcome.