CAJ | 학술논문

肿瘤可通过下调激发机体免疫系统必需成分的表达，或通过分泌免疫抑制因子等机制逃避机体的免疫监视和攻击，从而得以在体内生存和恶性增殖。利用基因工程技术修饰T细胞，设计一种可特异性识别肿瘤相关抗原的嵌合抗原受体，使其同时兼具细胞免疫治疗和抗体免疫治疗的优点，是近年来迅速发展的肿瘤过继免疫治疗方法。
종류가통과하조격발궤체면역계통필수성분적표체，혹통과분비면역억제인자등궤제도피궤체적면역감시화공격，종이득이재체내생존화악성증식。이용기인공정기술수식T세포，설계일충가특이성식별종류상관항원적감합항원수체，사기동시겸구세포면역치료화항체면역치료적우점，시근년래신속발전적종류과계면역치료방법。
Down-regulating the necessary component of immune system and suppressing pro-duction of immunosuppressive factors results in the tumor immune escape.Recently,the genetic modification of T cells with chimeric antigen receptors (CARs)was designed to solve the mechanism of escape immunosurveillance.The unique structure of CARs endows T cell tumor specific cytotoxici-ty and tumor antigen recognition ability.This adoptive antitumor immunotherapy develops rapidly and brings hope to the patients with tumors.