重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2014年
8期
935-936,940
,共3页
黏蛋白类%波形蛋白%直肠肿瘤%腺癌%肿瘤转移
黏蛋白類%波形蛋白%直腸腫瘤%腺癌%腫瘤轉移
점단백류%파형단백%직장종류%선암%종류전이
mucins%vimentin%rectum neoplasms%adenocarcinoma%neoplasms metastasis
目的：探讨N钙黏蛋白（neuronal cadherin ，N-cadherin）和波形蛋白（vimentin）在原发性直肠腺癌中的表达及其临床意义。方法选择手术切除并经病理证实的58例原发性直肠腺癌组织和距肿瘤5 cm以上的正常直肠黏膜组织，采用免疫组织化学SP法检测组织中N-cadherin和vimentin的表达并与临床资料进行相关性分析。结果直肠腺癌组织中N-cadherin和vim-entin阳性表达率[53．4％（31／58）、46．6％（27／58）]明显高于正常直肠黏膜组织[3．4％（2／58）、1．7％（1／58）]（P＜0．01）；N-cad-herin和vimentin的阳性率与肿瘤浸润深度、淋巴结转移、远处转移和 TNM 分期呈正相关（P＜0．05），与肿瘤分化程度无相关性（P＞0．05）。结论 N-cadherin和vimentin的表达与原发性直肠腺癌的转移密切相关，检测N-cadherin和vimentin的表达可作为判断直肠腺癌转移和预后的指标之一。
目的：探討N鈣黏蛋白（neuronal cadherin ，N-cadherin）和波形蛋白（vimentin）在原髮性直腸腺癌中的錶達及其臨床意義。方法選擇手術切除併經病理證實的58例原髮性直腸腺癌組織和距腫瘤5 cm以上的正常直腸黏膜組織，採用免疫組織化學SP法檢測組織中N-cadherin和vimentin的錶達併與臨床資料進行相關性分析。結果直腸腺癌組織中N-cadherin和vim-entin暘性錶達率[53．4％（31／58）、46．6％（27／58）]明顯高于正常直腸黏膜組織[3．4％（2／58）、1．7％（1／58）]（P＜0．01）；N-cad-herin和vimentin的暘性率與腫瘤浸潤深度、淋巴結轉移、遠處轉移和 TNM 分期呈正相關（P＜0．05），與腫瘤分化程度無相關性（P＞0．05）。結論 N-cadherin和vimentin的錶達與原髮性直腸腺癌的轉移密切相關，檢測N-cadherin和vimentin的錶達可作為判斷直腸腺癌轉移和預後的指標之一。
목적：탐토N개점단백（neuronal cadherin ，N-cadherin）화파형단백（vimentin）재원발성직장선암중적표체급기림상의의。방법선택수술절제병경병리증실적58례원발성직장선암조직화거종류5 cm이상적정상직장점막조직，채용면역조직화학SP법검측조직중N-cadherin화vimentin적표체병여림상자료진행상관성분석。결과직장선암조직중N-cadherin화vim-entin양성표체솔[53．4％（31／58）、46．6％（27／58）]명현고우정상직장점막조직[3．4％（2／58）、1．7％（1／58）]（P＜0．01）；N-cad-herin화vimentin적양성솔여종류침윤심도、림파결전이、원처전이화 TNM 분기정정상관（P＜0．05），여종류분화정도무상관성（P＞0．05）。결론 N-cadherin화vimentin적표체여원발성직장선암적전이밀절상관，검측N-cadherin화vimentin적표체가작위판단직장선암전이화예후적지표지일。
Objective To observe the expression of neuronal cadherin (N-cadherin) and vimentin in primary rectum adenocarci-noma tissues and their clinical value .Methods 58 cases of primary rectum adenocarcinoma tissues after surgical resection and con-firmed by pathology ,and normal rectum tissues that at lest 5 cm away from the tumor were selected .The immunohistochemical SP method was used to detect the expression of N-cadherin and vimentin and analyzed their correlation .Results In rectum adenocarci-noma tissues ,the positive expression rate of N-cadherin and vimentin[53 .4% (31/58) ,46 .6% (27/58)]were significantly higher than those of in normal rectum mucosa tissues[3 .4% (2/58) ,1 .7% (1/58)] ,(P<0 .01) .The expressions of N-cadherin and vimen-tin were positively correlated with the depth of cancer invasion ,lymph node metastasis ,distant metastasis and tumor-node-metasta-sis(TNM) stage(P<0 .05) ,but without correlated with the tumor cell differentiation(P>0 .05) .Conclusion N-cadherin and vim-entin have close relationships with metastasis of rectum adenocarcinoma ,to detect the expressions of N-cadherin and vimentin is of a effective method to judge the metastasis and prognosis of rectum adenocarcinoma .
