重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2014年
8期
930-931,934
,共3页
一氧化碳中毒%认知障碍%药物疗法%治疗结果
一氧化碳中毒%認知障礙%藥物療法%治療結果
일양화탄중독%인지장애%약물요법%치료결과
carbon monoxide poisoning%cognition disorders%drug therapy%treatment outcome
目的：观察奥拉西坦联合长春西汀注射液治疗一氧化碳中毒迟发性脑病（DEACMP）患者的临床疗效。方法将该院2009年8月至2012年11月收治的99例DEACMP患者分为对照组（49例）和治疗组（50例）。对照组给予长春西汀注射液每次30mg，每天1次；治疗组在对照组基础上加用奥拉西坦口服每次0．8g，每天3次。2周为1个疗程，疗程结束后观察比较两组的临床疗效，运用简易精神状态评估量表（MMSE）和蒙特利尔认知评估量表（MoCA）评价患者用药前后的认知功能。结果治疗组总有效率达92．0％，明显优于对照组（77．5％），差异有统计学意义（χ2＝4．019，P＝0．045）；治疗后两组患者MMSE和Mo-CA评分明显升高，与治疗前相比差异有统计学意义（P＜0．05），且治疗组评分高于对照组，差异有统计学意义（P＜0．05）。不良反应：治疗组有1例出现肌酐升高，1例丙氨酸氨基转移酶升高；对照组有2例出现恶心，食欲不振。结论奥拉西坦联合长春西汀注射液治疗DEACMP患者的临床疗效确切，安全性好，可明显改善患者的认知功能障碍。
目的：觀察奧拉西坦聯閤長春西汀註射液治療一氧化碳中毒遲髮性腦病（DEACMP）患者的臨床療效。方法將該院2009年8月至2012年11月收治的99例DEACMP患者分為對照組（49例）和治療組（50例）。對照組給予長春西汀註射液每次30mg，每天1次；治療組在對照組基礎上加用奧拉西坦口服每次0．8g，每天3次。2週為1箇療程，療程結束後觀察比較兩組的臨床療效，運用簡易精神狀態評估量錶（MMSE）和矇特利爾認知評估量錶（MoCA）評價患者用藥前後的認知功能。結果治療組總有效率達92．0％，明顯優于對照組（77．5％），差異有統計學意義（χ2＝4．019，P＝0．045）；治療後兩組患者MMSE和Mo-CA評分明顯升高，與治療前相比差異有統計學意義（P＜0．05），且治療組評分高于對照組，差異有統計學意義（P＜0．05）。不良反應：治療組有1例齣現肌酐升高，1例丙氨痠氨基轉移酶升高；對照組有2例齣現噁心，食欲不振。結論奧拉西坦聯閤長春西汀註射液治療DEACMP患者的臨床療效確切，安全性好，可明顯改善患者的認知功能障礙。
목적：관찰오랍서탄연합장춘서정주사액치료일양화탄중독지발성뇌병（DEACMP）환자적림상료효。방법장해원2009년8월지2012년11월수치적99례DEACMP환자분위대조조（49례）화치료조（50례）。대조조급여장춘서정주사액매차30mg，매천1차；치료조재대조조기출상가용오랍서탄구복매차0．8g，매천3차。2주위1개료정，료정결속후관찰비교량조적림상료효，운용간역정신상태평고량표（MMSE）화몽특리이인지평고량표（MoCA）평개환자용약전후적인지공능。결과치료조총유효솔체92．0％，명현우우대조조（77．5％），차이유통계학의의（χ2＝4．019，P＝0．045）；치료후량조환자MMSE화Mo-CA평분명현승고，여치료전상비차이유통계학의의（P＜0．05），차치료조평분고우대조조，차이유통계학의의（P＜0．05）。불량반응：치료조유1례출현기항승고，1례병안산안기전이매승고；대조조유2례출현악심，식욕불진。결론오랍서탄연합장춘서정주사액치료DEACMP환자적림상료효학절，안전성호，가명현개선환자적인지공능장애。
Objective To observe the clinical effects of oxiracetam combined vinpocetine injection in treatment of delayed en-cephalopathy after acute carbon monoxide poisoning .Methods 99 patients which were selected from August 2009 to November 2012 were randomly divided into control group(n=49) and treatment group(n=50) by stratified randomization method .The con-trol group was given hyperbaric oxygen therapy and vinpocetine for injection 30 mg/times ,1 time per day ,the treatment group was given hyperbaric oxygen therapy and vinpocetine for injection 30 mg/times ,1 time per day ,and oxiracetam 0 .8 g /times ,3 times per day .2 weeks for 1 treatment course ,clinical curative effect of two groups were compared after treatment ,the patients′scores of pre-therapy and post-therapy were assessed by mini mental state examination (MMSE) and montreal cognitive assessment scale (Mo-CA) .Results The total effective rate of treatment group was 92 .0% ,which was significantly better than the control group (77 .5% ) ,(χ2 =4 .019 ,P= 0 .045) .After treatment ,the patient′s score of MMSE and MoCA were increased significantly (P<0 .05) ,and scores of treatment group higher than the control group ,the difference was statistically significant (P<0 .05) .Adverse reactions :in the treatment group ,1 patient had elevated creatinine ,1 case of alanine aminotransferase ;2 patients had nausea ,loss of appetite in control group .Conclusion Oxiracetam combined vinpocetine for injection in the treatment of delayed encephalopathy af-ter acute carbon monoxide poisoning might have good clinical curative effects and security ,could obviously improve patients cogni-tive dysfunction .
