CAJ | 학술논문

目的：观察不同病理类型卵巢交界性肿瘤的临床特点，分析影响预后的相关因素。方法回顾性分析该科治疗的60例卵巢交界性肿瘤患者的临床资料，根据病理分型分为浆液组和黏液组，比较两组患者的临床特点，探讨影响预后的临床因素。结果60例卵巢交界性肿瘤以浆液性（n＝22，36．7％）和黏液性（n＝34，56．6％）为主，共占93．3％。浆液组和黏液组肿瘤大小、双侧卵巢累及率、肿瘤具多房性、呈乳头状、癌抗原（CA）125与CA19-9比较差异有统计学意义（P＜0．05）。56例患者均获得随访，5年总生存率和无瘤生存率分别为96．8％和94．2％。对5年无瘤生存率进行单因素分析，结果提示年龄、肿瘤大小、病理类型、是否绝经、手术方式、术后化疗、CA125、CA19-9等因素与患者预后无关；而国际妇产科联盟（FIGO ）分期、微浸润、腹膜种植与预后有关（P＜0．05）。多因素Logistic回归分析显示，FIGO分期低的患者预后更好（OR＝0．348，P＜0．05），而微浸润（OR＝8．458， P＜0．05）、腹膜种植（OR＝7．109，P＜0．05）是影响预后的危险因素。结论卵巢交界性肿瘤发病年龄轻，预后良好，且浆液性与黏液性卵巢交界性肿瘤具有一定的不同点。肿瘤FIGO分期、微浸润、腹膜种植可影响预后，对存在这些高危因素的患者应长期随访。
목적：관찰불동병리류형란소교계성종류적림상특점，분석영향예후적상관인소。방법회고성분석해과치료적60례란소교계성종류환자적림상자료，근거병리분형분위장액조화점액조，비교량조환자적림상특점，탐토영향예후적림상인소。결과60례란소교계성종류이장액성（n＝22，36．7％）화점액성（n＝34，56．6％）위주，공점93．3％。장액조화점액조종류대소、쌍측란소루급솔、종류구다방성、정유두상、암항원（CA）125여CA19-9비교차이유통계학의의（P＜0．05）。56례환자균획득수방，5년총생존솔화무류생존솔분별위96．8％화94．2％。대5년무류생존솔진행단인소분석，결과제시년령、종류대소、병리류형、시부절경、수술방식、술후화료、CA125、CA19-9등인소여환자예후무관；이국제부산과련맹（FIGO ）분기、미침윤、복막충식여예후유관（P＜0．05）。다인소Logistic회귀분석현시，FIGO분기저적환자예후경호（OR＝0．348，P＜0．05），이미침윤（OR＝8．458， P＜0．05）、복막충식（OR＝7．109，P＜0．05）시영향예후적위험인소。결론란소교계성종류발병년령경，예후량호，차장액성여점액성란소교계성종류구유일정적불동점。종류FIGO분기、미침윤、복막충식가영향예후，대존재저사고위인소적환자응장기수방。
Objective To observe the clinical features of different pathological borderline ovarian tumors and evaluate its prog-nostic factors .Methods The clinical data of 60 patients were retrospectively analyzed .Based on different histological types ,these patients were divided into serous borderline ovarian tumors group and mucins borderline ovarian tumors group .The clinical features was compared .Results 60 cases of epithelial borderline ovarian tumors contained 22(36 .7% ) serous borderline ovarian tumors and 34(56 .6% ) mucins borderline ovarian tumors .The tumor size ,ratio of bi-laterality ,multi-locular cyst ,papillary patterns ,level of CA-125 or CA19-9 had significant differences between the two groups(P<0 .05) .56 patients were followed up ,the 5-year overall survival and disease-free survival were 96 .8% and 94 .2% ,respectively .Univariate analysis of 5 years disease-free survival showed that ,age ,tumor size ,histological types ,menopause ,operation types ,chemotherapy and level of CA-125 or CA19-9 were irrelevant to prognosis of patients ,and FIGO stage ,micro-invasion ,peritoneal implants were relevant factors to prognosis .Multivariate analyses showed that ,the patients with low stage of FIGO (OR=0 .348 ,P<0 .05) had better prognosis ,while the patients with micro-inva-sion(OR= 8 .458 ,P< 0 .05) ,peritoneal implants (OR= 7 .109 ,P< 0 .05) had worse prognosis .Conclusion Borderline ovarian tumors frequently affected younger patients and has an excellent prognosis .there were some different clinical characteristics be-tween serous borderline ovarian tumors and mucins borderline ovarian tumors .All patients with borderline ovarian tumors should follow-up ,especially these who had high risks as micro-invasion ,peritoneal implants and high FIGO stage .