CAJ | 학술논문

目的：评价术前外周血中性／淋巴细胞比例（NLR）对直肠癌患者手术后生存的预测价值。方法选择该院2005～2007年住院行直肠癌根治术且随访资料完整的68例患者为研究对象，采用受试者工作曲线（ROC）截取最佳NLR截点值，分为高NLR组和低NLR组，比较两组术后生存率的状况。结果68例患者外周血NLR平均为（2．7±1．3），根据ROC曲线，NLR截点值为3．6时，对术后生存率的预测价值最高，预测灵敏度为81．3％，特异度为88．5％。以NLR3．6为最佳截点值，分为高NLR组和低NLR组，患者1、3、5年生存率分别为89．5％、57．9％、52．6％和95．9％、79．6％、75．5％，两组生存率比较差异有统计学意义（P＜0．05）。结论直肠癌患者术前外周血NLR的检测可以预测术后生存状况，高NLR预示患者生存状况不佳。
목적：평개술전외주혈중성／림파세포비례（NLR）대직장암환자수술후생존적예측개치。방법선택해원2005～2007년주원행직장암근치술차수방자료완정적68례환자위연구대상，채용수시자공작곡선（ROC）절취최가NLR절점치，분위고NLR조화저NLR조，비교량조술후생존솔적상황。결과68례환자외주혈NLR평균위（2．7±1．3），근거ROC곡선，NLR절점치위3．6시，대술후생존솔적예측개치최고，예측령민도위81．3％，특이도위88．5％。이NLR3．6위최가절점치，분위고NLR조화저NLR조，환자1、3、5년생존솔분별위89．5％、57．9％、52．6％화95．9％、79．6％、75．5％，량조생존솔비교차이유통계학의의（P＜0．05）。결론직장암환자술전외주혈NLR적검측가이예측술후생존상황，고NLR예시환자생존상황불가。
Objective To evaluate the predictive value of preoperative peripheral neutral to lymphocyte ratio (NLR) in patients with rectal cancer after operation .Methods 68 patients with rectal cancer who were admitted in our hospital from 2005 to 2007 year and had been completed follow-up after operation were collected .Receiver operating characteristic(ROC) was applied to cut the best cut-off point ,and the points divided into the high NLR group and low NLR group ,and then compared postoperative survival situation between two groups .Results The average of NLR of 68 patients was (2 .7 ± 1 .3) .The predictive value of the postopera-tive survival was high when NLR cut-off point was 3 .6 according to ROC ,predictive sensitivity was 81 .3% ,specificity was 88 .5% . The high and low NLR groups were divided according to NLR cut-off point 3 .6 ,the 1 ,3 ,5year survival rates in two groups were 89 .5% ,57 .9% ,52 .6% and 95 .9% ,79 .6% ,75 .5 % respectively ,the difference was statistically significant (P<0 .05) .Conclusion Preoperative NLR could predict survival situation of rectal cancer patients ,and the high NLR indicates poor survival condition .