CAJ | 학술논문

目的：研究阿德福韦酯联合还原型谷胱甘肽治疗失代偿期乙型肝炎后肝硬化的临床疗效。方法将76例失代偿期乙型肝炎后肝硬化患者分成观察组与对照组，每组38例。两组均采取对症支持治疗，观察组加用阿德福韦酯联合还原型谷胱甘肽治疗。3个月后观察两组患者肝功能、临床疗效及乙型肝炎病毒DNA定量。结果观察组治疗后肝功能改善，总有效率均优于对照组（P＜0．05），乙型肝炎病毒DNA转阴率显著优于对照组（P＜0．01）。结论阿德福韦酯联合还原型谷胱甘肽治疗失代偿期乙型肝炎后肝硬化可有效改善肝功能，促进乙型肝炎病毒DNA转阴，控制肝硬化失代偿的并发症，疗效确切。
목적：연구아덕복위지연합환원형곡광감태치료실대상기을형간염후간경화적림상료효。방법장76례실대상기을형간염후간경화환자분성관찰조여대조조，매조38례。량조균채취대증지지치료，관찰조가용아덕복위지연합환원형곡광감태치료。3개월후관찰량조환자간공능、림상료효급을형간염병독DNA정량。결과관찰조치료후간공능개선，총유효솔균우우대조조（P＜0．05），을형간염병독DNA전음솔현저우우대조조（P＜0．01）。결론아덕복위지연합환원형곡광감태치료실대상기을형간염후간경화가유효개선간공능，촉진을형간염병독DNA전음，공제간경화실대상적병발증，료효학절。
Objective To study the clinical efficay of the therapy adefovir dipivoxil combined with reduced glutathione in the treatment of decompensated hepatitis B cirrhosis .Methods 76 cases of decompensated hepatitis B cirrhosis were divided into the treatment group and the control group ,38 cases in each group .Both groups take symptomatic and supportive treatment ,the obser-vation group plus adefovir dipivoxil combined with glutathione therapy .After 3 months treatment ,we observed liver function ,hepa-titis B virus DNA quantification and assessed the clinical efficacy .Results After treatment ,the treatment group liver function im-proved was significantly better than the control group (P<0 .05) ,the total effective rate was higher than the control group (P<0 .05) ,the rate of hepatitis B virus DNA turn to negative was significantly higher than the control group (P<0 .01) .Conclusion Adefovir dipivoxil combined with reduced glutathione therapy for decompensated hepatitis B cirrhosis can effectively improve liver function ,suppress hepatitis B virus DNA undetectable ,reduce the incidence of the complication ,and worthy of promote in our clini-cal practice .