CAJ | 학술논문

目的：研究辛伐他汀剂量对老年高脂血症患者疗效与安全性的影响。方法选取老年高脂血症患者120例，随机分为两组，每组60例，分别给予辛伐他汀10 mg／d（10 mg／d剂量组）和20 mg／d（20 mg／d剂量组），疗程3个月。在治疗前后检测患者总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）水平，并记录疗效和不良反应。结果治疗后，两组患者TC、TG、LDL-C、HDL-C均较治疗前有所改善，差异有统计学意义（P＜0．05）；且20 mg／d剂量组疗效优于10 mg／d剂量组，差异有统计学意义（P＜0．05）；两组患者不良反应发生率之间的差异无统计学意义（P＞0．05）。结论20 mg／d剂量辛伐他汀对老年高脂血症患者疗效更好，且同样安全可靠。
목적：연구신벌타정제량대노년고지혈증환자료효여안전성적영향。방법선취노년고지혈증환자120례，수궤분위량조，매조60례，분별급여신벌타정10 mg／d（10 mg／d제량조）화20 mg／d（20 mg／d제량조），료정3개월。재치료전후검측환자총담고순（TC）、삼선감유（TG）、저밀도지단백담고순（LDL-C）、고밀도지단백담고순（HDL-C）수평，병기록료효화불량반응。결과치료후，량조환자TC、TG、LDL-C、HDL-C균교치료전유소개선，차이유통계학의의（P＜0．05）；차20 mg／d제량조료효우우10 mg／d제량조，차이유통계학의의（P＜0．05）；량조환자불량반응발생솔지간적차이무통계학의의（P＞0．05）。결론20 mg／d제량신벌타정대노년고지혈증환자료효경호，차동양안전가고。
Objective To study the efficacy and safety of different simvastatin doses on hyperlipidemia in the elderly .Methods 120 patients with hyperlipidemia were randomly divided into two groups ,60 cases in each group ,patients were given simvastatin 10 mg/d(10 mg/d group) or 20 mg/d(20 mg/d group) .Data were collected before and after treatment ,including total cholesterol (TC) ,three acyl glycerin (TG) ,low density lipoprotein cholesterol (LDL-C) ,high density lipoprotein cholesterol (HDL-C) ,treat-ment efficacy and adverse reactions events .Results 3 month after treatment ,TC ,TG ,LDL-C and HDL-C were better than before treatment in both groups(P<0 .05);and the curative effect in 20 mg/d group was better than 10 mg/d group(P<0 .05) .There was no significant difference in incidence of adverse reactions events between the two groups (P>0 .05) .Conclusion 20 mg/d simvasta-tin is better than 10 mg/d simvastatin in efficacy of elderly patients with hyperlipidemia ,and offers a safe and reliable treatment .