CAJ | 학술논문

目的：探讨幽门螺杆菌（Hp）根除对肠易激综合征（IBS）或慢传输型便秘（STC）的长短期疗效及Hp感染在IBS和STC病因中的地位。方法收集伴随功能性消化不良及Hp感染（13C或14C呼气试验阳性）的IBS或STC患者共98例，均给予7dHp根除治疗。治疗后1个月复查13C或14C呼气试验。依据呼气试验结果将患者分为Hp阳性组和Hp阴性组。分别对根除前、根除治疗后第1天、根除治疗后1个月的排便习惯、大便性状等进行评分并比较。结果87例患者Hp成功根除，11例失败。在Hp阳性组，Hp根除前、根除治疗后第1天、根除治疗后1个月之间比较，各型IBS、STC的总有效率降低（P＜0．05）。在根除治疗后第1天Hp阴性组腹泻型IBS总有效率最高，STC最低（P＜0．05）。但根除治疗后第1天和根除治疗后1个月比较，各型IBS、STC总有效率均下降（P＜0．05）。结论Hp根除不能对IBS或STC产生长期疗效，Hp感染不是IBS或STC的主要病因。Hp根除治疗可使部分患者的排便习惯、大便性状等短期改善，这可能是肠道菌群改变所致。
목적：탐토유문라간균（Hp）근제대장역격종합정（IBS）혹만전수형편비（STC）적장단기료효급Hp감염재IBS화STC병인중적지위。방법수집반수공능성소화불량급Hp감염（13C혹14C호기시험양성）적IBS혹STC환자공98례，균급여7dHp근제치료。치료후1개월복사13C혹14C호기시험。의거호기시험결과장환자분위Hp양성조화Hp음성조。분별대근제전、근제치료후제1천、근제치료후1개월적배편습관、대편성상등진행평분병비교。결과87례환자Hp성공근제，11례실패。재Hp양성조，Hp근제전、근제치료후제1천、근제치료후1개월지간비교，각형IBS、STC적총유효솔강저（P＜0．05）。재근제치료후제1천Hp음성조복사형IBS총유효솔최고，STC최저（P＜0．05）。단근제치료후제1천화근제치료후1개월비교，각형IBS、STC총유효솔균하강（P＜0．05）。결론Hp근제불능대IBS혹STC산생장기료효，Hp감염불시IBS혹STC적주요병인。Hp근제치료가사부분환자적배편습관、대편성상등단기개선，저가능시장도균군개변소치。
Objective To explore the short and long-term therapeutic effect of helicobacter pylori (Hp) eradication and patho-genic role of Hp infection in the irritable bowel syndrome(IBS) and slow transit constipation(STC) .Methods 98 patients with pos-itive Hp infection which determined by 13C or 14C breath test ,suffered with either the IBS or STC and with concomitant dyspep-sia ,were treated with 7 days regimen of Hp eradication .All cases were re-examined with the 13C or 14C breath test one month after treatment and then divided into Hp positive group and Hp negative group according to the positive or negative Hp infection .And both groups were scored on the change of the habitual defecation and the stool consistency before one day and one month after Hp eradication .Results Hp infection in 87 cases was successfully eradicated ,11 cases failed .Among the Hp positive group ,the total effective rate decreased in comparison with before ,one day ,one month after Hp treatment (P<0 .05) .And among the Hp negative group ,the highest therapeutic effect was found in the diarrhea-IBS and lowest in the STC was found in the first day after treatment (P<0 .05) .Compared with the first day after treatment ,both IBS and STC showed significantly decreased therapeutic effect one month after Hp treatment(P<0 .05) .Conclusion Hp eradication couldn′t induce long term therapeutic effect in IBS and STC , which indicate Hp infection plays a minor role in the pathogenesis of both IBS and STC .The short term improvement of the defeca-tion and the stool consistence in some patients may relate to the change of the gut microbiota .