中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2014年
6期
831-833
,共3页
心绞痛%阿托伐他汀%氯吡格雷%老年人
心絞痛%阿託伐他汀%氯吡格雷%老年人
심교통%아탁벌타정%록필격뢰%노년인
Angina pectoris%Atorvastatin%Clopidogrel%Aged
目的 探讨阿托伐他汀联合氯吡格雷治疗老年人心绞痛的疗效和安全性.方法 90例老年心绞痛患者按数字表法随机分为观察组和对照组,每组45例.所有患者均应用常规和阿托伐他汀治疗,观察组在此基础上加用氯吡格雷.比较两组治疗前后TC、TG、HDL-C、LDL-C、心绞痛发作次数、持续时间及不良反应、心脏不良事件,并评价疗效.结果 观察组总有效率为93.3％(42/45),对照组为75.6％(34/45),差异有统计学意义(x2=5.67,P ＜0.05).两组治疗后TC、TG、HDL-C、LDL-C均较治疗前显著改善(t=5.34、4.78、4.56、4.92、4.31、3.92、4.11、4.62,均P＜0.05),观察组改善显著优于对照组(t=4.20、4.08、3.98、4.03,均P＜0.05).两组治疗后心绞痛发作次数和持续时间均较治疗前显著下降(t=6.22、5.78、4.12、4.02,均P＜0.05),且观察组较对照组下降更为显著(t=4.23、3.99,均P＜0.05).观察组不良反应3例,心脏不良事件1例,对照组不良反应2例,心脏不良事件3例.结论 阿托伐他汀联合氯吡格雷治疗老年人心绞痛既能调脂,又能改善心绞痛症状.
目的 探討阿託伐他汀聯閤氯吡格雷治療老年人心絞痛的療效和安全性.方法 90例老年心絞痛患者按數字錶法隨機分為觀察組和對照組,每組45例.所有患者均應用常規和阿託伐他汀治療,觀察組在此基礎上加用氯吡格雷.比較兩組治療前後TC、TG、HDL-C、LDL-C、心絞痛髮作次數、持續時間及不良反應、心髒不良事件,併評價療效.結果 觀察組總有效率為93.3％(42/45),對照組為75.6％(34/45),差異有統計學意義(x2=5.67,P ＜0.05).兩組治療後TC、TG、HDL-C、LDL-C均較治療前顯著改善(t=5.34、4.78、4.56、4.92、4.31、3.92、4.11、4.62,均P＜0.05),觀察組改善顯著優于對照組(t=4.20、4.08、3.98、4.03,均P＜0.05).兩組治療後心絞痛髮作次數和持續時間均較治療前顯著下降(t=6.22、5.78、4.12、4.02,均P＜0.05),且觀察組較對照組下降更為顯著(t=4.23、3.99,均P＜0.05).觀察組不良反應3例,心髒不良事件1例,對照組不良反應2例,心髒不良事件3例.結論 阿託伐他汀聯閤氯吡格雷治療老年人心絞痛既能調脂,又能改善心絞痛癥狀.
목적 탐토아탁벌타정연합록필격뢰치료노년인심교통적료효화안전성.방법 90례노년심교통환자안수자표법수궤분위관찰조화대조조,매조45례.소유환자균응용상규화아탁벌타정치료,관찰조재차기출상가용록필격뢰.비교량조치료전후TC、TG、HDL-C、LDL-C、심교통발작차수、지속시간급불량반응、심장불량사건,병평개료효.결과 관찰조총유효솔위93.3％(42/45),대조조위75.6％(34/45),차이유통계학의의(x2=5.67,P ＜0.05).량조치료후TC、TG、HDL-C、LDL-C균교치료전현저개선(t=5.34、4.78、4.56、4.92、4.31、3.92、4.11、4.62,균P＜0.05),관찰조개선현저우우대조조(t=4.20、4.08、3.98、4.03,균P＜0.05).량조치료후심교통발작차수화지속시간균교치료전현저하강(t=6.22、5.78、4.12、4.02,균P＜0.05),차관찰조교대조조하강경위현저(t=4.23、3.99,균P＜0.05).관찰조불량반응3례,심장불량사건1례,대조조불량반응2례,심장불량사건3례.결론 아탁벌타정연합록필격뢰치료노년인심교통기능조지,우능개선심교통증상.
Objective To investigate the efficacy and safety of atorvastatin combined with clopidogrel in the treatment of elderly patients with angina pectoris.Methods 90 elderly patients with angina pectoris were randomly divided into the observation group and control group,45 cases in each group.All patients were given conventional treatment and atorvastatin,the observation group was given clopidogrel based on this.The TC,TG,HDL-C,LDL-C,angina attack frequency,duration and adverse reactions,adverse cardiac events of two groups before and after treatment were compared,and the clinical effect was evaluated.Results The total effective rate of the observation group was 9 3.3 ％ (42/45),whichwassignificantlyhigherthan75.6％ (34/45) inthecontrolgroup (x2 =5.67,P ＜ 0.05).After treatment,the TC,TG,HDL-C,LDL-C of two groups were significantly improved than before treatment (t =5.34,4.78,4.56,4.92,4.31,3.92,4.11,4.62,all P ＜ 0.05),the improvement in the observation group was significantly better than that in the control group (t =4.20,4.08,3.98,4.03,all P ＜ 0.05).After treatment,the angina attack frequency and duration of two groups were significantly decreased compared with before treatment (t =6.22,5.78,4.12,4.02,all P ＜ 0.05),and the observation group decreased significantly than the control group(t =4.23,3.99,all P ＜ 0.05).3 cases of adverse reactions and 1 case of adverse cardiac events occurred in observation group,2 cases of adverse reaction and 3 cases of adverse cardiac events occurred in control group.Conclusion Atorvastatin combined with clopidogrel in the treatment of elderly patients with angina pectoris can regulate blood lipid and improve the symptoms of angina pectoris.
