CAJ | 학술논문

传统治疗糖尿病组织病变的方法主要有药物及外科治疗,近年来干细胞移植治疗糖尿病并发症在动物模型及临床上均取得了一定的成果,其中应用较多的有胚胎干细胞、间充质干细胞和内皮祖细胞,其治疗糖尿病组织病变的机制主要与其参与新生血管形成、启动和分泌相关因子、免疫调节以及干细胞的增殖和分化能力等有关.现主要从干细胞的分类及其特征,其治疗糖尿病皮肤创伤及下肢血管病变、糖尿病心肌病变、肾脏病变、周围神经病变等及其作用机制进行综述.
전통치료당뇨병조직병변적방법주요유약물급외과치료,근년래간세포이식치료당뇨병병발증재동물모형급림상상균취득료일정적성과,기중응용교다적유배태간세포、간충질간세포화내피조세포,기치료당뇨병조직병변적궤제주요여기삼여신생혈관형성、계동화분비상관인자、면역조절이급간세포적증식화분화능력등유관.현주요종간세포적분류급기특정,기치료당뇨병피부창상급하지혈관병변、당뇨병심기병변、신장병변、주위신경병변등급기작용궤제진행종술.
Traditional therapies of tissue repair of diabetes are mainly medication and surgery,while stem cell transplantation has made great progress in the treatment of diabetic complications in animal models and clinical outcomes,some of which are embryonic stem cells,mesenchymal stem cells and endothelial progenitor cells.The mechanism of stem cells to treat diabetic complications includes its participation in new blood vessels forming,starting and secreting some related factors,immune regulation,proliferation and differentiation,etc.The classification and characteristics of stem cells,and the mechanism of therapy of diabetic skin trauma and lower extremity vascular lesions,diabetic cardiomyopathy,nephropathy,peripheral neuropathy etc are reviewed.