CAJ | 학술논문

目的：揭示第一代H1受体拮抗剂马来酸氯苯那敏参与癫痫发作的剂量关系,评价神经毒性.方法：昆明种小鼠腹腔给与不同剂量马来酸氯苯那敏注射液,初步评价马来酸氯苯那敏的对抗异烟肼诱导癫痫的活性和神经毒性.然后进行了定量评价.结果：在低剂量下不仅不能诱发受试动物癫痫,而且还可以拮抗化学诱导剂异烟肼诱发的各种癫痫,在高剂量时极易引起动物自身癫痫.结论：提示马来酸氯苯那敏在不同剂量下具有双重性,在使用时,尤其是注射液时应加以注意.
목적：게시제일대H1수체길항제마래산록분나민삼여전간발작적제량관계,평개신경독성.방법：곤명충소서복강급여불동제량마래산록분나민주사액,초보평개마래산록분나민적대항이연정유도전간적활성화신경독성.연후진행료정량평개.결과：재저제량하불부불능유발수시동물전간,이차환가이길항화학유도제이연정유발적각충전간,재고제량시겁역인기동물자신전간.결론：제시마래산록분나민재불동제량하구유쌍중성,재사용시,우기시주사액시응가이주의.
Objective: To reveal the dose relationship between first-generation H1 receptor antagonist chlorpheniramine maleate and epilepsy,and evaluate its neurotoxicity.Methods: Kunming mice were given different doses of chlorpheniramine maleate injection via peritoneal cavity to accomplish a preliminary evaluation of chlorpheniramine maleate against isoniazid-induced epileptic activity and its neurotoxicity.Then the quantitative evaluation was conducted.Results: At low doses chlorpheniramine maleate could not induce epilepsy in the tested animals.Instead,it antagonized the isoniazid-induced seizures.At high doses it could easily cause the animal's own epilepsy.Conclusion: Chlorpheniramine maleate has a dual nature related to doses.The close attention should be paid to the dose of chlorpheniramine maleate injection in its application.