内蒙古民族大学学报：自然科学版
內矇古民族大學學報：自然科學版
내몽고민족대학학보：자연과학판
Journal of Inner Mongolia University for the Nationalities(Natural Sciences)
2012年
3期
262-265
,共4页
溶剂挥发%克拉霉素%微胶囊%羟丙基甲基纤维素
溶劑揮髮%剋拉黴素%微膠囊%羥丙基甲基纖維素
용제휘발%극랍매소%미효낭%간병기갑기섬유소
Solvent evaporation%Clarithromycin%Microcapsule%Hydroxypropyl methyl cellulose
以克拉霉素为模型药物,乙基纤维素与羟丙基甲基纤维素为膜材料,采用溶剂挥发法制备混合膜微胶囊,探索制备的最佳条件,并考察混合膜微胶囊的缓控释性能.实验结果表明,混合膜克拉霉素微胶囊的最佳制备条件为∶分散相中膜材料浓度为3%、乙基纤维素/羟丙基甲基纤维素为6∶1~7∶1、投药量2∶1~3∶1、连续相中SDS浓度0.1%、PVA浓度1.0%、油水比1∶8.
以剋拉黴素為模型藥物,乙基纖維素與羥丙基甲基纖維素為膜材料,採用溶劑揮髮法製備混閤膜微膠囊,探索製備的最佳條件,併攷察混閤膜微膠囊的緩控釋性能.實驗結果錶明,混閤膜剋拉黴素微膠囊的最佳製備條件為∶分散相中膜材料濃度為3%、乙基纖維素/羥丙基甲基纖維素為6∶1~7∶1、投藥量2∶1~3∶1、連續相中SDS濃度0.1%、PVA濃度1.0%、油水比1∶8.
이극랍매소위모형약물,을기섬유소여간병기갑기섬유소위막재료,채용용제휘발법제비혼합막미효낭,탐색제비적최가조건,병고찰혼합막미효낭적완공석성능.실험결과표명,혼합막극랍매소미효낭적최가제비조건위∶분산상중막재료농도위3%、을기섬유소/간병기갑기섬유소위6∶1~7∶1、투약량2∶1~3∶1、련속상중SDS농도0.1%、PVA농도1.0%、유수비1∶8.
Prepared the mixed film microcapsule by solvent evaporation when clarithromycin is model drug,ethyl cellulose and hydroxypropyl methyl cellulose is membrane materials.Explored the optimumexperimental conditions and investigated into relaxed controlled release property of mixed film microcapsule.The experimental results show that the optimum experimental conditions of preparing the mixed film microcapsule are gained.Conclusions when membrane materials concentration is 3% in dispersed phase,ethyl cellulose/hydroxypropyl methyl cellulose is 6∶1~7∶1,drug dosage is 2∶1~ 3∶1,SDS concentration is 0.1%,PVA concentration is 1.0% in continuous phase and volume ratio of oil/water is 1∶8.
