广州化学
廣州化學
엄주화학
GUANGZHOU CHEMISTRY
2012年
4期
12-17
,共6页
张有德%赵明%邵自强%王飞後%姚培源
張有德%趙明%邵自彊%王飛後%姚培源
장유덕%조명%소자강%왕비후%요배원
纤维素%药用辅料%胶囊%成膜性%玻璃化转变温度
纖維素%藥用輔料%膠囊%成膜性%玻璃化轉變溫度
섬유소%약용보료%효낭%성막성%파리화전변온도
cellulose%pharmaceutical raw materials%capsule%film forming ability%glass transition temperature
利用WDW-10kN型微机控制电子式万能试验机和DSC-60型自动差示扫描量热仪,研究了日本信越和湖州展望低黏羟丙基甲基纤维素(HPMC)、羧甲基纤维素(CMC)、卡拉胶、明胶以及复配材料的成膜性和所成膜的性能。结果表明,HPMC及其复配样品均具有较好的成膜性,而且所成膜均具有很好的均匀性和透光性。明胶的成膜时间较长,所成膜易产生霉点,在生产时需加入防腐剂。HPMC的断裂属于韧性断裂,断裂延伸率较大,而加入卡拉胶后断裂延伸率有所降低。明胶的拉伸曲线呈脆性断裂,其断裂延伸率相对较小,而强度最大。HPMC与卡拉胶有很好的相容性,可以在一定程度上降低生产植物胶囊的成本。随着人们对植物胶囊的了解,以及国内外公众用药理念的转变,植物胶囊的市场需求将迅速增长。
利用WDW-10kN型微機控製電子式萬能試驗機和DSC-60型自動差示掃描量熱儀,研究瞭日本信越和湖州展望低黏羥丙基甲基纖維素(HPMC)、羧甲基纖維素(CMC)、卡拉膠、明膠以及複配材料的成膜性和所成膜的性能。結果錶明,HPMC及其複配樣品均具有較好的成膜性,而且所成膜均具有很好的均勻性和透光性。明膠的成膜時間較長,所成膜易產生黴點,在生產時需加入防腐劑。HPMC的斷裂屬于韌性斷裂,斷裂延伸率較大,而加入卡拉膠後斷裂延伸率有所降低。明膠的拉伸麯線呈脆性斷裂,其斷裂延伸率相對較小,而彊度最大。HPMC與卡拉膠有很好的相容性,可以在一定程度上降低生產植物膠囊的成本。隨著人們對植物膠囊的瞭解,以及國內外公衆用藥理唸的轉變,植物膠囊的市場需求將迅速增長。
이용WDW-10kN형미궤공제전자식만능시험궤화DSC-60형자동차시소묘량열의,연구료일본신월화호주전망저점간병기갑기섬유소(HPMC)、최갑기섬유소(CMC)、잡랍효、명효이급복배재료적성막성화소성막적성능。결과표명,HPMC급기복배양품균구유교호적성막성,이차소성막균구유흔호적균균성화투광성。명효적성막시간교장,소성막역산생매점,재생산시수가입방부제。HPMC적단렬속우인성단렬,단렬연신솔교대,이가입잡랍효후단렬연신솔유소강저。명효적랍신곡선정취성단렬,기단렬연신솔상대교소,이강도최대。HPMC여잡랍효유흔호적상용성,가이재일정정도상강저생산식물효낭적성본。수착인문대식물효낭적료해,이급국내외공음용약이념적전변,식물효낭적시장수구장신속증장。
With WDW-10 kN type microcomputer control electronic universal testing machine and DSC-60 type automatic differential scanning calorimetric apparatus, the film forming abilityand the performance of the film of the low viscosity HPMC of Japan Shlngtsu ancl tiuznou Outlook, CMC, carrageenan, gelatin and the compound with sample were studied. Results showed that the HPMC and its compound with sample are good film forming ability, and the film all has the very good uniformity and pervious to light quality. Gelatin filmed for a long time, the film easily generated mildew and need join preservatives in production. HPMC fracture belongs to the ductile fracture, the breaking elongation rate is bigger, and the breaking elongation rate reduced after joining earrageenan. Gelatin tensile curve is brittle fracture, and the elongation was relatively small, while the biggest strength. HPMC and carrageenan has good compatibility, can to a certain extent, reduce the cost of production plant capsule. As people to plant capsule of uncierstanding, and the public at home and abroad medication concept change, plant capsule market demand will be rapid growth.