宜宾学院学报
宜賓學院學報
의빈학원학보
JOURNAL OF YIBIN UNIVERSITY
2012年
6期
47-49
,共3页
严春蓉%李兰%吴凯群%王玉良
嚴春蓉%李蘭%吳凱群%王玉良
엄춘용%리란%오개군%왕옥량
4-羟基-3-喹啉羧酸酯类抗球虫化合物%合成%亚硝化%催化加氢%缩合%醚化%关环
4-羥基-3-喹啉羧痠酯類抗毬蟲化閤物%閤成%亞硝化%催化加氫%縮閤%醚化%關環
4-간기-3-규람최산지류항구충화합물%합성%아초화%최화가경%축합%미화%관배
4-hydroxy-3-quinolinecarboxylates anticoccidial compounds%synthesis%nitrification%catalytic hydrogenation%condensation%etherification%closed loop response
经过亚硝化、催化加氢、缩合、醚化和关环等五步反应，设计并合成了两个新型 4-羟基-3-喹啉羧酸酯类抗球虫化合物．新化合物的合成具有合成路线短、产率高、原料易得、易实现工业化等优点．所有化合物的结构均经1H NMR，IR 和 HRMS 等方法确证．
經過亞硝化、催化加氫、縮閤、醚化和關環等五步反應，設計併閤成瞭兩箇新型 4-羥基-3-喹啉羧痠酯類抗毬蟲化閤物．新化閤物的閤成具有閤成路線短、產率高、原料易得、易實現工業化等優點．所有化閤物的結構均經1H NMR，IR 和 HRMS 等方法確證．
경과아초화、최화가경、축합、미화화관배등오보반응，설계병합성료량개신형 4-간기-3-규람최산지류항구충화합물．신화합물적합성구유합성로선단、산솔고、원료역득、역실현공업화등우점．소유화합물적결구균경1H NMR，IR 화 HRMS 등방법학증．
Two novel 4-hydroxy-3-quinolinecarboxylates anticoccidial compounds were designed and synthesized through five-step reactions of nitrification,catalytic hydrogenation,condensation,etherification and closed loop response.The new process is characterized by a short synthetic route,high yield and cheap raw material,which is convenient for the commercial production.The structures of these compounds are confirmed by 1H NMR,IR spectra and HRMS.
