CAJ | 학술논문

4-（4-羟基苯基）乙基儿茶酚是一种新型幽门螺旋杆菌尿素酶抑制剂，运用酶动力学研究方法，对它的抑制机理、抑制类型进行探讨．实验结果表明，4-（4-羟基苯基）乙基儿茶酚是尿素酶的竞争性抑制剂，抑制常数K：为1．48／μmol／L，为其在抗胃炎、胃溃疡方面的应用以及进一步的结构优化奠定了理论基础．
4-（4-간기분기）을기인다분시일충신형유문라선간균뇨소매억제제，운용매동역학연구방법，대타적억제궤리、억제류형진행탐토．실험결과표명，4-（4-간기분기）을기인다분시뇨소매적경쟁성억제제，억제상수K：위1．48／μmol／L，위기재항위염、위궤양방면적응용이급진일보적결구우화전정료이론기출．
4-(4-Hydroxyphenethyl) benzene-l, 2-diol is a new inhibitor against Helicobacter Pylori ure- ase. The inhibition mechanism was herein investigated through enzyme kinetics methods,and the results revealed that 4-(4-hydroxyphenethyl)benzene-1,2-diol was competitive inhibitor of urease with a Ki val- ue of 1.48 t~mol/L. The chemical stabilitiy and the competitive mechanism of 4-(4-hydroxyphenethyl)- benzene-1,2-diol strongly suggested that it could be used as a lead compound for rational drug design to find active compound and as a potential urease inhibitor for treatment of gastritis and peptic ulcer.