CAJ | 학술논문

在硫酸介质中，硫酸铈氧化亚硫酸钠产生微弱的发光信号，而雷尼替丁可显著增强该体系的化学发光，由此建立了流动注射化学发光技术测定雷尼替丁的新体系．实验结果表明，该方法的检出限为9．8×10-7mol／L，测定雷尼替丁的线性范围为3．0×10-6～2．5×10-4mol／L．对5．0×10-5mol／L雷尼替丁进行11次平行测定，其相对标准偏差为3．3％．将该方法用于药物胶囊中雷尼替丁的测定，结果令人满意．
재류산개질중，류산시양화아류산납산생미약적발광신호，이뢰니체정가현저증강해체계적화학발광，유차건립료류동주사화학발광기술측정뢰니체정적신체계．실험결과표명，해방법적검출한위9．8×10-7mol／L，측정뢰니체정적선성범위위3．0×10-6～2．5×10-4mol／L．대5．0×10-5mol／L뢰니체정진행11차평행측정，기상대표준편차위3．3％．장해방법용우약물효낭중뢰니체정적측정，결과령인만의．
A new chemiluminescence method for determination of ranitidine is proposed. The method is based on the enhancement of ranitidine on the chemiluminescence reaction among cerium sulphate and sodium sulfite in He SO4 medium. The linear relationship between the intensity of chemiluminescence and the concentration of ranitidine is in the range of 3.0×10-6~2.5× 10-4 mol/L with the detection limit of 9.8× 10-r mol/L. The relative standard deviation is 3.3% for]l measurements of 5.0× 10 a mol/L ran itidine standard solution. This method has been successfully applied to determination of ranitidine in in jections and drug capsules with satisfactory results.