CAJ | 학술논문

许多天然产物和药物活性分子往往因为季碳中心的存在而表现出更好的理化性质和生物活性．文章首先以氢化钠作碱，利用酮和酯反应得到了一系列的α-取代-1，3-二羰基化合物，收率50％～87％；然后进一步通过烯丙基化反应成功合成了具有3个官能团（2个羰基和1个烯基）的季碳砌块，产率为50％～93％．并对合成的α-取代-1，3-二羰基化合物和烯丙基化产物进行了1HNMR表征．
허다천연산물화약물활성분자왕왕인위계탄중심적존재이표현출경호적이화성질화생물활성．문장수선이경화납작감，이용동화지반응득도료일계렬적α-취대-1，3-이탄기화합물，수솔50％～87％；연후진일보통과희병기화반응성공합성료구유3개관능단（2개탄기화1개희기）적계탄체괴，산솔위50％～93％．병대합성적α-취대-1，3-이탄기화합물화희병기화산물진행료1HNMR표정．
Many natural products and active pharmaceutical molecules with quaternary carbon center tend to show better physical and chemical properties and biological activity. Herein a series of α-substituted-1 ,3- dicar- bonyl compounds were synthesized from the reaction between ketone and ester with sodium hydride as base and then were allylated to construct quaternary synthetical building-block with muhifunctional groups in yield 75 % to 93%. All the products were characterized by 1H NMR.