昆明医科大学学报
昆明醫科大學學報
곤명의과대학학보
Journal of Kunming Medical University
2014年
2期
145-147,151
,共4页
张海燕%黄汉飞%曾仲
張海燕%黃漢飛%曾仲
장해연%황한비%증중
p38%肝脏%缺血再灌注损伤
p38%肝髒%缺血再灌註損傷
p38%간장%결혈재관주손상
p38%liver%ischemia reperfusion injury
肝脏缺血再灌注损伤(hepatic ischemia reperfusion injury, HIRI)是临床上一种较为常见的病理生理现象,也是目前肝脏外科及肝移植临床研究的难点和热点问题,p38丝裂原活化蛋白激酶(mitogen activated protein kinase,MAPK)在多种疾病和应激条件下被大量激活,p38信号传导途径的激活是导致肝脏缺血再灌注损伤的重要机制之一,就近年来有关p38信号通路在肝脏缺血再灌注损伤中的作用及机制研究进行综述。
肝髒缺血再灌註損傷(hepatic ischemia reperfusion injury, HIRI)是臨床上一種較為常見的病理生理現象,也是目前肝髒外科及肝移植臨床研究的難點和熱點問題,p38絲裂原活化蛋白激酶(mitogen activated protein kinase,MAPK)在多種疾病和應激條件下被大量激活,p38信號傳導途徑的激活是導緻肝髒缺血再灌註損傷的重要機製之一,就近年來有關p38信號通路在肝髒缺血再灌註損傷中的作用及機製研究進行綜述。
간장결혈재관주손상(hepatic ischemia reperfusion injury, HIRI)시림상상일충교위상견적병리생리현상,야시목전간장외과급간이식림상연구적난점화열점문제,p38사렬원활화단백격매(mitogen activated protein kinase,MAPK)재다충질병화응격조건하피대량격활,p38신호전도도경적격활시도치간장결혈재관주손상적중요궤제지일,취근년래유관p38신호통로재간장결혈재관주손상중적작용급궤제연구진행종술。
Hepatic ischemia-reperfusion injury,a relatively common phenomenon in clinical pathophysiology, is one of the currently difficult and hot issues in liver surgery and liver transplantation clinical studies. p38 mitogen activated protein kinases are activated in a variety of diseases and stress conditions. p38 signaling pathway activation is one of the important mechanisms leading to hepatic ischemia-reperfusion injury. This article reviews the roles and mechanisms of P38 signaling pathway recently years in the liver ischemia reperfusion injury.