宜春学院学报
宜春學院學報
의춘학원학보
JOURNAL OF YICHUN UNIVERSITY
2012年
12期
77-79
,共3页
廖波%高镕%熊梨花%易国萍%李彦%万绍兰%盛志坚%刘名根%方巧%万洁%欧阳衡
廖波%高镕%熊梨花%易國萍%李彥%萬紹蘭%盛誌堅%劉名根%方巧%萬潔%歐暘衡
료파%고용%웅리화%역국평%리언%만소란%성지견%류명근%방교%만길%구양형
轻度认知功能障碍%蒙特利尔认知评估%ApoEe4等位基因%早期评估
輕度認知功能障礙%矇特利爾認知評估%ApoEe4等位基因%早期評估
경도인지공능장애%몽특리이인지평고%ApoEe4등위기인%조기평고
Mild Cognitive Impairment%Montreal Cognitive Assessment%ApoliPoprotein Ee4 Allele%Early E- valuation
目的：探索早期识别和降低老年人轻度认知功能障碍（MCI）患病率的途径。方法：随机选择调查宜眷市399名60岁以上老年人，进行蒙特利尔认知评估（北京版）（MoCA）、哈金斯基缺血指数评分（HIS）、日常生活能力量表（ADL）等测查。并选取符合MCI诊断标准者和正常老年人各40例，抽取全血样本检测其ApoEε4等位基因进行对照研究。结果：共有符合MCI诊断标准者41名，患病率为10．28％。MCI患病率随增龄而增高，与受教育水平成反比，农村显著高于城市，体力劳动者显著高于脑力劳动者；在性别及婚姻状态上其差异无统计学意义。MCI组ApoEε4等位基因携带及频率分布与正常老年人组相比有显著差异（P〈0．05）。结论：低教育水平、体力劳动者、生活在农村地区、高龄对MCI的患病有显著影响，ApoEε4基因携带可能是MCI患病的危险因素。对重点人群进行MoCA评估及ApoEε4基因测定，并进行相应干预，有助于减少和预防MCI的发生。
目的：探索早期識彆和降低老年人輕度認知功能障礙（MCI）患病率的途徑。方法：隨機選擇調查宜眷市399名60歲以上老年人，進行矇特利爾認知評估（北京版）（MoCA）、哈金斯基缺血指數評分（HIS）、日常生活能力量錶（ADL）等測查。併選取符閤MCI診斷標準者和正常老年人各40例，抽取全血樣本檢測其ApoEε4等位基因進行對照研究。結果：共有符閤MCI診斷標準者41名，患病率為10．28％。MCI患病率隨增齡而增高，與受教育水平成反比，農村顯著高于城市，體力勞動者顯著高于腦力勞動者；在性彆及婚姻狀態上其差異無統計學意義。MCI組ApoEε4等位基因攜帶及頻率分佈與正常老年人組相比有顯著差異（P〈0．05）。結論：低教育水平、體力勞動者、生活在農村地區、高齡對MCI的患病有顯著影響，ApoEε4基因攜帶可能是MCI患病的危險因素。對重點人群進行MoCA評估及ApoEε4基因測定，併進行相應榦預，有助于減少和預防MCI的髮生。
목적：탐색조기식별화강저노년인경도인지공능장애（MCI）환병솔적도경。방법：수궤선택조사의권시399명60세이상노년인，진행몽특리이인지평고（북경판）（MoCA）、합금사기결혈지수평분（HIS）、일상생활능역량표（ADL）등측사。병선취부합MCI진단표준자화정상노년인각40례，추취전혈양본검측기ApoEε4등위기인진행대조연구。결과：공유부합MCI진단표준자41명，환병솔위10．28％。MCI환병솔수증령이증고，여수교육수평성반비，농촌현저고우성시，체력노동자현저고우뇌력노동자；재성별급혼인상태상기차이무통계학의의。MCI조ApoEε4등위기인휴대급빈솔분포여정상노년인조상비유현저차이（P〈0．05）。결론：저교육수평、체력노동자、생활재농촌지구、고령대MCI적환병유현저영향，ApoEε4기인휴대가능시MCI환병적위험인소。대중점인군진행MoCA평고급ApoEε4기인측정，병진행상응간예，유조우감소화예방MCI적발생。
Objective: To explore the approach of early identification and reduced prevalence with mild cognitive impairment. Methods: A sample of 399 elder people aged 60 or above living in Yichun area were examined with Montreal cognitive assessment (MoCA), Hachinski ischemia index score table (HIS) and active daily living assessment (ADL) . A control study was carried out between 40 patients with MIC and 40 healthy elderly subjects testing Apolipoprotein Ee4 allele (ApoEε4) . Result: Among the subjects visited, 41 (10. 28% ) were defined to have MIC. The prevalence rate of MIC was higher in people living in rural area, in people with lower educational attainment, and in people who were labor workers. The prevalence increased with age growing. There was no statistical significance in sex and marital status. ApoEε4 was significantly increased in MIC group vs normal group ( P 〈 0. 05) . Result: Advanced age, living in rural area, labor workers and lower educational attainmenthas remarkable effect on MIC. ApoEε4 might be the risk factors in MIC. Testing ApoEa-4 and examining MoCA on the key population is helpful to reduce and preventing MIC.
