CAJ | 학술논문

目的总结bcr-abl融合基因阳性急性淋巴细胞白血病(ALL)患儿临床特点,探讨其治疗及预后的相关因素.方法对经反转录聚合酶链反应(RT-PCR)方法检测bcr-abl融合基因阳性的7例ALL患儿临床表现、治疗、预后进行回顾性分析.结果 bcr-abl融合基因阳性ALL患儿7例,平均发病年龄为8岁1个月,均为B细胞型ALL,治疗第33天骨髓完全缓解率为50％.结论 bcr-abl融合基因阳性ALL患儿化疗效果差,难缓解,复发率高,预后差.
목적 총결bcr-abl융합기인양성급성림파세포백혈병(ALL)환인림상특점,탐토기치료급예후적상관인소.방법 대경반전록취합매련반응(RT-PCR)방법검측bcr-abl융합기인양성적7례ALL환인림상표현、치료、예후진행회고성분석.결과 bcr-abl융합기인양성ALL환인7례,평균발병년령위8세1개월,균위B세포형ALL,치료제33천골수완전완해솔위50％.결론 bcr-abl융합기인양성ALL환인화료효과차,난완해,복발솔고,예후차.
Objective To analyze the clinical features of pediatric patients with acute lymphoblastic leukemia(ALL) with bcr-abl fusion gene transcript,and discuss the treatment,prognosis factors of this kind of ALL.Methods Clinical features,treatment and prognosis were studied retrospectively in 7 bcr-abl fusion gene positive ALL patients.bcr-abl fusion gene was detected by reverse transcription polymerase chain reaction (RT-PCR).Results The average age of the 7 patients was 8 years and 1 month old.All of them were common B-immunology ALL.The rate of complete response was 50 ％ after 33 days' treatment.Conclusions The incidence rate of bcr-abl fusion gene positive ALL in pediatric is low.This type of ALL has poor remission,high relapse rate and poor prognosis.