广州化工
廣州化工
엄주화공
GUANGZHOU CHEMICAL INDUSTRY AND TECHNOLOGY
2012年
24期
104-105
,共2页
邻硝基苯氧乙酸%合成%工艺改进
鄰硝基苯氧乙痠%閤成%工藝改進
린초기분양을산%합성%공예개진
2-(2-nitrophenoxy) acetic acid%synthesis%improvement
以邻硝基苯酚和氯乙酸甲酯为原料,在碳酸钾催化下反应生成邻硝基苯氧乙酸甲酯,经碱水解、盐酸酸化得目标产物。通过实验考察了缩合反应温度,碱用量对产率的影响,得出最佳反应条件：温度为72℃,碱用量为邻硝基苯氧乙酸甲酯的1.5倍,在此条件下总产率达到78.9%。新方法原料易得、耗时短、收率高、后处理简单,工业化生产前景广阔。
以鄰硝基苯酚和氯乙痠甲酯為原料,在碳痠鉀催化下反應生成鄰硝基苯氧乙痠甲酯,經堿水解、鹽痠痠化得目標產物。通過實驗攷察瞭縮閤反應溫度,堿用量對產率的影響,得齣最佳反應條件：溫度為72℃,堿用量為鄰硝基苯氧乙痠甲酯的1.5倍,在此條件下總產率達到78.9%。新方法原料易得、耗時短、收率高、後處理簡單,工業化生產前景廣闊。
이린초기분분화록을산갑지위원료,재탄산갑최화하반응생성린초기분양을산갑지,경감수해、염산산화득목표산물。통과실험고찰료축합반응온도,감용량대산솔적영향,득출최가반응조건：온도위72℃,감용량위린초기분양을산갑지적1.5배,재차조건하총산솔체도78.9%。신방법원료역득、모시단、수솔고、후처리간단,공업화생산전경엄활。
2-(2-nitrophenoxy) acetic acid was obtained by three steps,using 2-nitrophenol and methyl 2-chloroacetate as starting materials and potassium carbonate as catalyst.The effect of reaction temperature and amount of sodium hydroxide on the yield were studied.When the reaction temperature was 72 ℃ and the amount of sodium hydroxide was 1.5 times as that of methyl 2-(2-nitrophenoxy) acetate and the yield reached 78.9%.New method had the advantages of convenient operation,mild reaction conditions and cheap reagents and was suitable for industrial process.
