CAJ | 학술논문

目的探讨复方敏维糖浆对慢性荨麻疹患者血清IL-4和干扰素-γ(IFN-γ)的影响.方法 189例慢性荨麻疹患者作为观察组,60例非过敏性疾病患者作为对照组,对观察组进行复方敏维糖浆治疗,平均治疗7d.治疗前后测定两组血清IL-4和IFN-γ,观察不良反应.结果经治疗后,观察组痊愈123例,显效34例,有效23例,无效9例,总有效率为95.2％;观察组治疗前血清IL-4较对照组明显升高(t=3.729,P＜0.01)、IFN-γ较对照组明显降低(t=3.064,P＜0.01);观察组治疗后血清IL-4比治疗前明显降低(t=2.778,P＜0.05)、IFN--y比对照组明显升高(t=2.467,P＜0.05).观察组出现轻度嗜睡、困倦2例,停药后症状消失.结论复方敏维糖浆可明显改善慢性荨麻疹患者的IL-4和IFN-γ平衡.
목적 탐토복방민유당장대만성담마진환자혈청IL-4화간우소-γ(IFN-γ)적영향.방법 189례만성담마진환자작위관찰조,60례비과민성질병환자작위대조조,대관찰조진행복방민유당장치료,평균치료7d.치료전후측정량조혈청IL-4화IFN-γ,관찰불량반응.결과 경치료후,관찰조전유123례,현효34례,유효23례,무효9례,총유효솔위95.2％;관찰조치료전혈청IL-4교대조조명현승고(t=3.729,P＜0.01)、IFN-γ교대조조명현강저(t=3.064,P＜0.01);관찰조치료후혈청IL-4비치료전명현강저(t=2.778,P＜0.05)、IFN--y비대조조명현승고(t=2.467,P＜0.05).관찰조출현경도기수、곤권2례,정약후증상소실.결론 복방민유당장가명현개선만성담마진환자적IL-4화IFN-γ평형.
Objective To study the effect of compound Minwei syrup on serum interleukin-4 (IL-4) and interferon-γ(IFN-γ) in patients with chronic urticaria.Methods 189 patients with chronic urticaria were enrolled as the observation group,60 cases of non-allergic diseases were selected as the control group.The observation group was treated by compound Minwei syrup for average 7 days.Serum levels of IL-4 and IFN-γbefore and after treatment were detected.Results After treatment,in the observation group 123 cases recovered,34 cases had marked effect,effective in 23 cases,9 cases without effect,the total effective rate was 95.2％.Serum IL-4 in the observation group before treament was significantly higher than the control group(t =3.729,P ＜ 0.01),IFN-γwas significantly lower than the control group(t =3.064,P ＜ 0.01).After treatment,serum IL-4 in the observation group was significantly lower than before treatment (t =2.778,P ＜ 0.05),1FN-γwas significantly higher than the control group (t =2.467,P ＜ 0.05).Mild drowsiness and sleepiness appeared in 2 patients in the observation group,symptoms disappeared after drug withdrawal.Conclusion Minwei syrup can significantly improve IL-4 and IFN-γ balance in patients with chronic urticaria.