CAJ | 학술논문

胰腺癌上调因子(PAUF)是新近发现的癌基因.其在胰腺癌高表达,能够通过激活CXCR4、β-catenin、TPL2/MEK/ERK、FAK/Scr等信号通路,增加胰腺癌细胞间的黏附性,促进胰腺癌血管生成及增加血管通透性等方式来促进胰腺癌迁徙、转移及进展.同时这些信号通路与吉西他滨耐药密切相关.因此我们推测PAUF亦参与调节吉西他滨对胰腺癌细胞的耐药.目前国内外尚缺乏PAUF调节胰腺癌细胞吉西他滨耐药及其机制方面的研究.因此,对其进行深入研究有利于明确胰腺癌化疗耐药机制及为胰腺癌治疗提供新的靶点.
이선암상조인자(PAUF)시신근발현적암기인.기재이선암고표체,능구통과격활CXCR4、β-catenin、TPL2/MEK/ERK、FAK/Scr등신호통로,증가이선암세포간적점부성,촉진이선암혈관생성급증가혈관통투성등방식래촉진이선암천사、전이급진전.동시저사신호통로여길서타빈내약밀절상관.인차아문추측PAUF역삼여조절길서타빈대이선암세포적내약.목전국내외상결핍PAUF조절이선암세포길서타빈내약급기궤제방면적연구.인차,대기진행심입연구유리우명학이선암화료내약궤제급위이선암치료제공신적파점.
Pancreatic adenocarcinoma up-regulated factor(PAUF),a newly discovered gene,is highly expressed in pancreatic cancer.PAUF promotes the metastasis and progression of pancreatic cancer through many ways,such as the activation of signal pathway (CXCR4,β-catenin,TPL2/MEK/ERK,FAK/Scr),increasing the adhesiveness of pancreatic cancer cells,promoting angiogenesis and vascular permeability.Simultaneously,CXCR4,β-catenin,TPL2/MEK/ERK and FAK/Scr are closely related with gemcitabine-resistance.Based on this theory,we infer that PAUF plays a role in gemcitabine-resistance of pancreatic cancer cells.So far,no related research has been done domestic and overseas.The research may find a clue for the mechanism of chemotherapy-resistance and provide a new target spot for the therapy of pancreatic cancer.