中华航空航天医学杂志
中華航空航天醫學雜誌
중화항공항천의학잡지
CHINESE JOURNAL OF AEROSPACE MEDICINE
2013年
2期
91-94
,共4页
朱业%李婷%张莹%揭晓姝
硃業%李婷%張瑩%揭曉姝
주업%리정%장형%게효주
高脂血症%内皮,血管%血脂异常
高脂血癥%內皮,血管%血脂異常
고지혈증%내피,혈관%혈지이상
Hyperlipidemias%Endothelium,vascular%Dyslipidemias
目的 研究民航飞行员高脂血症患者循环内皮微颗粒(endothelial microparticles,EMPs)水平的变化,探讨其与高脂血症的关系. 方法 收集2011年度南方航空公司飞行员体检资料,根据随机数字表法选取年龄35～45岁的男性民航飞行员43名.根据高脂血症诊断标准,将其分为2组,其中高脂血症飞行员20名(高脂血症组),血脂水平正常的飞行员23名(对照组),以流式细胞术检测两组飞行员血浆中的CD31+/CD42b-EMPs水平,并分析其与TC、TG和LDL-C的关系.结果 高脂血症组和对照组比较,TC、TG和LDL-C差异均有统计学意义(t=6.397、5.734、7.490,P＜0.01)；与对照组相比,高脂血症组飞行员血浆中的EMPs水平显著升高(t=20.570,P＜0.01)；EMPs水平与TC、TG和LDL-C水平呈明显正相关(r=0.8403、0.8003、0.7668,P＜0.01).结论 EMPs水平升高反应内皮损伤及功能障碍,是高脂血症患者血管内皮受损的敏感指标,也可预测飞行员的心血管功能将进一步恶化,因此对高脂血症飞行员需采取针对性措施开展预防和治疗.
目的 研究民航飛行員高脂血癥患者循環內皮微顆粒(endothelial microparticles,EMPs)水平的變化,探討其與高脂血癥的關繫. 方法 收集2011年度南方航空公司飛行員體檢資料,根據隨機數字錶法選取年齡35～45歲的男性民航飛行員43名.根據高脂血癥診斷標準,將其分為2組,其中高脂血癥飛行員20名(高脂血癥組),血脂水平正常的飛行員23名(對照組),以流式細胞術檢測兩組飛行員血漿中的CD31+/CD42b-EMPs水平,併分析其與TC、TG和LDL-C的關繫.結果 高脂血癥組和對照組比較,TC、TG和LDL-C差異均有統計學意義(t=6.397、5.734、7.490,P＜0.01)；與對照組相比,高脂血癥組飛行員血漿中的EMPs水平顯著升高(t=20.570,P＜0.01)；EMPs水平與TC、TG和LDL-C水平呈明顯正相關(r=0.8403、0.8003、0.7668,P＜0.01).結論 EMPs水平升高反應內皮損傷及功能障礙,是高脂血癥患者血管內皮受損的敏感指標,也可預測飛行員的心血管功能將進一步噁化,因此對高脂血癥飛行員需採取針對性措施開展預防和治療.
목적 연구민항비행원고지혈증환자순배내피미과립(endothelial microparticles,EMPs)수평적변화,탐토기여고지혈증적관계. 방법 수집2011년도남방항공공사비행원체검자료,근거수궤수자표법선취년령35～45세적남성민항비행원43명.근거고지혈증진단표준,장기분위2조,기중고지혈증비행원20명(고지혈증조),혈지수평정상적비행원23명(대조조),이류식세포술검측량조비행원혈장중적CD31+/CD42b-EMPs수평,병분석기여TC、TG화LDL-C적관계.결과 고지혈증조화대조조비교,TC、TG화LDL-C차이균유통계학의의(t=6.397、5.734、7.490,P＜0.01)；여대조조상비,고지혈증조비행원혈장중적EMPs수평현저승고(t=20.570,P＜0.01)；EMPs수평여TC、TG화LDL-C수평정명현정상관(r=0.8403、0.8003、0.7668,P＜0.01).결론 EMPs수평승고반응내피손상급공능장애,시고지혈증환자혈관내피수손적민감지표,야가예측비행원적심혈관공능장진일보악화,인차대고지혈증비행원수채취침대성조시개전예방화치료.
Objective To study the change of vascular endothelial microparticles (EMPs) levels in the civil pilots with hyperlipoidemia disease and its relationship with hyperlipoidemia.Methods Forty-three pilots,aged from 35 to 45,were selected as subjects by means of random number table upon the review of annual physical examination of China Southern Airlines pilots in 2011.According to the diagnosis standard for hyperlipoidemia,43 pilots were divided into hyperlipoidemia group (n=20) and control group (n=23).The levels of CD31+/CD42b EMPs in pilots' plasma were measured by flow cytometry,and their relationships with TC,TG and LDL-C were analyzed.Results There were significant differences in TC,TG,LDL-C between two groups (t=6.397,5.734,7.490,P＜0.01).Hyperlipoidemia group showed higher levels of EMPs (t=20.570,P＜0.01).There were positive correlations between the levels of EMPs and TC,TG and LDL C concentration (r=0.8403,0.8003,0.7668,P＜0.01).Conclusions The high EMPs levels reflect the endothelium injuries and dysfunction,which are the sensitive indicators to vessel endothelium injuries and can forecast that pilot's cardiovascular function would deteriorate further.Therefore,it is suggested that the prevention measures and treatment for the pilots with hyperlipoidemia should be strengthened.
