中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
16期
2454-2456
,共3页
布地奈德%噻托溴铵%雾化%COPD%炎症因子%临床应用
佈地奈德%噻託溴銨%霧化%COPD%炎癥因子%臨床應用
포지내덕%새탁추안%무화%COPD%염증인자%림상응용
Pulmicort Respules%Tiotropium Bromide%Atomization%COPD%Inflammatory cytokines%Clinical application
目的 观察布地奈德联合噻托溴铵雾化吸入治疗COPD的临床疗效及对气道炎症因子水平的影响.方法 将130例符合入组标准急性发作期的COPD按数字表法随机分为观察组65例和对照组65例,两组患者均进行常规综合治疗,对照组再单独雾化吸入布地奈德治疗,观察组在对照组基础上,再吸入噻托溴 铵,两组均治疗14 d,观察治疗前后患者症状与体征,进行呼吸功能及血气监测,诱导痰测定气道炎症因子水平.结果 (1)治疗后,观察组FEV1、FEV1/预计值、FEV1/FVC、PaO2明显升高,而PaCO2明显降低,但对照组治疗后FEV1/FVC没有明显改变；(2)两组治疗前各肺功能与血气指标差异没有统计学意义,具有可比性,观察组治疗后FEV1、FEV1/预计值、FEV1/FVC、PaO2明显升高于对照组,PaCO2明显低于对照组；(3)治疗后,两组IL-8、TNF-α、中性粒细胞比例均较治疗前明显降低；(4)两组治疗前IL-8、TNF-α、中性粒细胞比例差异没有统计学意义,具有可比性,观察组治疗后IL-8、TNF-α、中性粒细胞比例明显低于对照组.结论 布地奈德联合噻托溴铵雾化吸入治疗COPD能靶向性地到达病灶部位,缓解症状与减轻气道炎症并施,保护提高肺通气功能,效果优于单纯布地奈德的治疗效果,是治疗COPD的理想方法.
目的 觀察佈地奈德聯閤噻託溴銨霧化吸入治療COPD的臨床療效及對氣道炎癥因子水平的影響.方法 將130例符閤入組標準急性髮作期的COPD按數字錶法隨機分為觀察組65例和對照組65例,兩組患者均進行常規綜閤治療,對照組再單獨霧化吸入佈地奈德治療,觀察組在對照組基礎上,再吸入噻託溴 銨,兩組均治療14 d,觀察治療前後患者癥狀與體徵,進行呼吸功能及血氣鑑測,誘導痰測定氣道炎癥因子水平.結果 (1)治療後,觀察組FEV1、FEV1/預計值、FEV1/FVC、PaO2明顯升高,而PaCO2明顯降低,但對照組治療後FEV1/FVC沒有明顯改變；(2)兩組治療前各肺功能與血氣指標差異沒有統計學意義,具有可比性,觀察組治療後FEV1、FEV1/預計值、FEV1/FVC、PaO2明顯升高于對照組,PaCO2明顯低于對照組；(3)治療後,兩組IL-8、TNF-α、中性粒細胞比例均較治療前明顯降低；(4)兩組治療前IL-8、TNF-α、中性粒細胞比例差異沒有統計學意義,具有可比性,觀察組治療後IL-8、TNF-α、中性粒細胞比例明顯低于對照組.結論 佈地奈德聯閤噻託溴銨霧化吸入治療COPD能靶嚮性地到達病竈部位,緩解癥狀與減輕氣道炎癥併施,保護提高肺通氣功能,效果優于單純佈地奈德的治療效果,是治療COPD的理想方法.
목적 관찰포지내덕연합새탁추안무화흡입치료COPD적림상료효급대기도염증인자수평적영향.방법 장130례부합입조표준급성발작기적COPD안수자표법수궤분위관찰조65례화대조조65례,량조환자균진행상규종합치료,대조조재단독무화흡입포지내덕치료,관찰조재대조조기출상,재흡입새탁추 안,량조균치료14 d,관찰치료전후환자증상여체정,진행호흡공능급혈기감측,유도담측정기도염증인자수평.결과 (1)치료후,관찰조FEV1、FEV1/예계치、FEV1/FVC、PaO2명현승고,이PaCO2명현강저,단대조조치료후FEV1/FVC몰유명현개변；(2)량조치료전각폐공능여혈기지표차이몰유통계학의의,구유가비성,관찰조치료후FEV1、FEV1/예계치、FEV1/FVC、PaO2명현승고우대조조,PaCO2명현저우대조조；(3)치료후,량조IL-8、TNF-α、중성립세포비례균교치료전명현강저；(4)량조치료전IL-8、TNF-α、중성립세포비례차이몰유통계학의의,구유가비성,관찰조치료후IL-8、TNF-α、중성립세포비례명현저우대조조.결론 포지내덕연합새탁추안무화흡입치료COPD능파향성지도체병조부위,완해증상여감경기도염증병시,보호제고폐통기공능,효과우우단순포지내덕적치료효과,시치료COPD적이상방법.
Objective To observe the effect of Pulmicort Respules combined with Tiotropium Bromide in the treatment of chronic obstructive pulmonary disease (COPD) and its influence on inflammatory cytokines.Methods 130 COPD patients which met inclusion criteria were randomly divided into the observation group (65 cases) and control group (65 cases).Both two groups were given conventional therapy,the control group was given a separate aerosol inhalation of Pulmicort Respules,the observation group was inhaled Tiotropium Bromide on the basis of the control group.Both two groups were treated for 14d,the symptoms and signs were observed before and after treatment.The respiratory function and blood gas were monitored,and induced sputum was used to determine inflammatory cytokines levels of airway.Results (1) After treatment,the FEV1,FEV1/predicted,FEVi/FVC,PaO2 of the observation group were significantly increased,the PaCO2 was significantly reduced,but FEV1/FVC of the control group had no significant change after treatment.(2) The lung function and blood gas between the two groups had no statistically significant differences before treatment.After treatment,the FEV1,FEV1/predicted,FEV1/FVC,PaO2 of observation group were obviously higher than those of the control group,PaCO2 was significantly lower than the control group.(3) After treatment,the IL-8,TNF-α,neutrophil cell ratio of two groups were significantly lower than before treatment.(4) The IL-8,TNF-α,neutrophil cell ratio had no statistically significant differences before treatment between two groups.After treatment,the IL-8,TNF-α,neutrophil cell ratio of observation group were significantly lower than control group.Conclusion Pulmicort Respules combined with Tiotropium Bromide in the treatment of COPD can be targeted to the lesion site,and relieve symptoms,reduce airway inflammation,improve pulmonary function,the effect was better than simplely use Pulmicort Respules.
