中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2013年
3期
278-281
,共4页
姜志昕%宋慧%汤欣%马丽华
薑誌昕%宋慧%湯訢%馬麗華
강지흔%송혜%탕흔%마려화
重组人表皮生长因子%白内障超声乳化手术%角膜水肿%角膜容积
重組人錶皮生長因子%白內障超聲乳化手術%角膜水腫%角膜容積
중조인표피생장인자%백내장초성유화수술%각막수종%각막용적
Recombinant human epidermal growth factor%Phacoemulsification%Corneal edema%Corneal volume
目的 探讨重组人表皮生长因子(rhEGF)滴眼液对年龄相关性白内障超声乳化联合人工晶状体植入术后角膜水肿的疗效.方法 临床病例随机对照研究.选取透明角膜切口白内障超声乳化联合人工晶状体植入术后发生角膜水肿或角膜切口水肿的患者51例(54只眼),随机分为治疗组(rhEGF组)和对照组,对照组采用妥布霉素地塞米松滴眼液等常规治疗,治疗组加用重组人表皮生长因子滴眼液(易贝滴眼液),观察术后角膜水肿程度、Pentacam测量角膜中央3 mm、5 mm、7 mm直径范围内的角膜容积和角膜内皮镜观察中央角膜内皮细胞密度.采用正态性和方差齐性检验,两组独立样本资料的t检验、配对t检验等对数据进行统计学分析.结果 角膜水肿情况显示,治疗组在术后3d和7d角膜水肿程度均低于对照组,差异均有统计学意义(P＜0.05).角膜容积显示,术后7d时两组之间的CV3、CV5和CV7相比较,差异均有统计学意义(P＜0.05),且rhEGF治疗组均小于对照组.角膜内皮镜检查结果显示,术后1月时1级角膜水肿的病例,rhEGF治疗组的角膜内皮丢失率小于对照组,差异有统计学意义(P＜0.05).结论 重组人表皮生长因子对年龄相关性白内障术后早期角膜水肿有明显的疗效.
目的 探討重組人錶皮生長因子(rhEGF)滴眼液對年齡相關性白內障超聲乳化聯閤人工晶狀體植入術後角膜水腫的療效.方法 臨床病例隨機對照研究.選取透明角膜切口白內障超聲乳化聯閤人工晶狀體植入術後髮生角膜水腫或角膜切口水腫的患者51例(54隻眼),隨機分為治療組(rhEGF組)和對照組,對照組採用妥佈黴素地塞米鬆滴眼液等常規治療,治療組加用重組人錶皮生長因子滴眼液(易貝滴眼液),觀察術後角膜水腫程度、Pentacam測量角膜中央3 mm、5 mm、7 mm直徑範圍內的角膜容積和角膜內皮鏡觀察中央角膜內皮細胞密度.採用正態性和方差齊性檢驗,兩組獨立樣本資料的t檢驗、配對t檢驗等對數據進行統計學分析.結果 角膜水腫情況顯示,治療組在術後3d和7d角膜水腫程度均低于對照組,差異均有統計學意義(P＜0.05).角膜容積顯示,術後7d時兩組之間的CV3、CV5和CV7相比較,差異均有統計學意義(P＜0.05),且rhEGF治療組均小于對照組.角膜內皮鏡檢查結果顯示,術後1月時1級角膜水腫的病例,rhEGF治療組的角膜內皮丟失率小于對照組,差異有統計學意義(P＜0.05).結論 重組人錶皮生長因子對年齡相關性白內障術後早期角膜水腫有明顯的療效.
목적 탐토중조인표피생장인자(rhEGF)적안액대년령상관성백내장초성유화연합인공정상체식입술후각막수종적료효.방법 림상병례수궤대조연구.선취투명각막절구백내장초성유화연합인공정상체식입술후발생각막수종혹각막절구수종적환자51례(54지안),수궤분위치료조(rhEGF조)화대조조,대조조채용타포매소지새미송적안액등상규치료,치료조가용중조인표피생장인자적안액(역패적안액),관찰술후각막수종정도、Pentacam측량각막중앙3 mm、5 mm、7 mm직경범위내적각막용적화각막내피경관찰중앙각막내피세포밀도.채용정태성화방차제성검험,량조독립양본자료적t검험、배대t검험등대수거진행통계학분석.결과 각막수종정황현시,치료조재술후3d화7d각막수종정도균저우대조조,차이균유통계학의의(P＜0.05).각막용적현시,술후7d시량조지간적CV3、CV5화CV7상비교,차이균유통계학의의(P＜0.05),차rhEGF치료조균소우대조조.각막내피경검사결과현시,술후1월시1급각막수종적병례,rhEGF치료조적각막내피주실솔소우대조조,차이유통계학의의(P＜0.05).결론 중조인표피생장인자대년령상관성백내장술후조기각막수종유명현적료효.
ObJective To evaluate the clinical efficacy of recombinant human epidermal growth factor in treatment of corneal edema after cataract phacoemulsification.Methods Fifty-one (54 eyes) patients with corneal edema caused by clear corneal incision phacoemulsification and intraocular lens implantation were randomly divided into treatment group and control group.Control group using tobramycin and dexamethasone eye drops and other conventional treatment,the treatment group received recombinant human epidermal growth factor,observed corneal edema subsided case corneal volume (CV) and central corneal endothelial cell density (CED).The variants in the study were tested using two independent sample t-test,paired t-test,adjusted chi square test,Fisher's exact probabilities.Results The level of corneal edema in the treated group was lower than that of in the control group (P ＜0.05).The corneal volume at 3.0 mm,5.0mm and 7.0mm in the treated group were lower than those of in the control group (P ＜0.05) in the 7 days after surgery.The central corneal endothelial cell density in the treated group was more than that of in the control group (P ＜0.05) in the 1 month after surgery.Conclusions Recombinant human epidermal growth factor has exact and obvious efficacy for early corneal edema after cataract phacoemulsification.
