CAJ | 학술논문

　　非核糖体肽（non-ribosomal peptides, NRPs）是一类主要由氨基酸（包括特殊的或修饰过的氨基酸）及羟基酸组成的小分子化合物，它不在核糖体上合成，而是通过所谓的硫模板多聚酶机制（thiotemplate multienzyme mechanism）的多酶复合系统合成的一类肽类次级代谢产物。NRPs的功能主要包括免疫抑制剂、抗生素、细胞增殖抑制剂、铁载体或离子载体等。虫生真菌产生的非核糖体肽毒素目前主要发现8种，即efrapeptin、环孢菌素（cyclosporin）、绿僵菌素（destruxin）、白僵菌素（beauvericin）、恩镰菌素（enniatin）、球孢交酯（bassianolide）、白僵交酯（beauverolide）和 serinocyclin，本文介绍上述毒素的种类、结构、活性与作用机理，为相关研究者提供参考。
　　비핵당체태（non-ribosomal peptides, NRPs）시일류주요유안기산（포괄특수적혹수식과적안기산）급간기산조성적소분자화합물，타불재핵당체상합성，이시통과소위적류모판다취매궤제（thiotemplate multienzyme mechanism）적다매복합계통합성적일류태류차급대사산물。NRPs적공능주요포괄면역억제제、항생소、세포증식억제제、철재체혹리자재체등。충생진균산생적비핵당체태독소목전주요발현8충，즉efrapeptin、배포균소（cyclosporin）、록강균소（destruxin）、백강균소（beauvericin）、은렴균소（enniatin）、구포교지（bassianolide）、백강교지（beauverolide）화 serinocyclin，본문개소상술독소적충류、결구、활성여작용궤리，위상관연구자제공삼고。
Non-ribosomal peptides are small molecular compounds mainly composed of specific or modified amino acids and oxyacids. They are synthesized via thiotemplate multienzyme mechanism of multifunctional enzyme complex system other than on ribosome. NRPs show a broad range of biological activities, functions of non-ribosomal peptides mainly include antibiotics, immunity inhibitor, cell proliferation inhibitor, siderophore or ionophore, etc. There are eight primary kinds of non-ribosomal peptides produced by entomogenous fungi, inculding efrapeptin, cyclosporin, destruxin, beauvericin, enniatin, bassianolide, beauverolide and serinocyclin. The types, structures, activity, mechanism of these NRPs were reviewed to provide a reference for researchers interested in NPRs.