CAJ | 학술논문

目的探讨不同糖耐量人群血清淀粉样蛋白A的水平,及与血管内皮功能的关系.方法 59例患者根据OGTT试验分为3组:19例NGT、20例IGT和20例T2DM.分别检测血清淀粉样蛋白A、生化指标、肱动脉内皮依赖性舒张功能(FMD)和含服硝酸甘油后肱动脉内皮依赖性舒张功能(NID).结果 ①SAA随着血糖的升高而升高,DM组的SAA较IGT组、NGT组明显升高(P＜0.01),IGT组的SAA较NGT组升高(P＜0.05).②FMD随着SAA的升高而下降,DM组的FMD较IGT组和NGT组明显降低(P＜0.01),IGT组的FMD较NGT组降低(P＜0.05).③Spearman相关分析显示SAA与FBG、HbA1c、TC均呈正相关(r值分别为0.63、0.48、0.59,P＜0.01),与FMD呈显著负相关(r值为-0.62,P＜0.01).结论 SAA与血管内皮功能损害密切相关.
목적 탐토불동당내량인군혈청정분양단백A적수평,급여혈관내피공능적관계.방법 59례환자근거OGTT시험분위3조:19례NGT、20례IGT화20례T2DM.분별검측혈청정분양단백A、생화지표、굉동맥내피의뢰성서장공능(FMD)화함복초산감유후굉동맥내피의뢰성서장공능(NID).결과 ①SAA수착혈당적승고이승고,DM조적SAA교IGT조、NGT조명현승고(P＜0.01),IGT조적SAA교NGT조승고(P＜0.05).②FMD수착SAA적승고이하강,DM조적FMD교IGT조화NGT조명현강저(P＜0.01),IGT조적FMD교NGT조강저(P＜0.05).③Spearman상관분석현시SAA여FBG、HbA1c、TC균정정상관(r치분별위0.63、0.48、0.59,P＜0.01),여FMD정현저부상관(r치위-0.62,P＜0.01).결론 SAA여혈관내피공능손해밀절상관.
Objective To investigate the level of serum amyloid A in patients with different glucose intolerance,and its correlation with vascular endothelial function.Methods 59 cases were divided into three groups by oral glucose tolerance test (OGTT):19 cases of normal glucose tolerance (NGT),20 cases of impaired glucose tolerance (IGT) and 20 cases of type 2 diabetes (DM).Serum amyloid A and other biochemical indices were measured.Color Doppler examination was followed to evaluate flow-mediated vasodilation (FMD),nitroglycerin vasodilation (NID).Results ① SAA was increased with the increment of Glucose.In DM group,SAA was higher than that in IGT group and NGT group(P ＜ 0.05),while the difference between IGT group and NGT group was also significant (P ＜ 0.05).② FMD was significantly decreased in contrast to the increment of SAA,in DM group,FMD was lower than that in IGT group and NGT group(P ＜ 0.05),while the difference between IGT group and NGT group was also significant(P ＜ 0.05).③ Spearman regressive analysis showed that SAA was positively related to FBG,HbA1c,TC (r=0.63,0.48,0.59,P ＜ 0.001),while negatively with FMD (r=-0.62,P ＜ 0.001).Conclusion SAA is closely related to vascular endothelial dysfunction.