CAJ | 학술논문

目的探讨骨肉瘤组织中钙结合蛋白S100A4和锌指转录因子Snail的表达及意义.方法应用免疫组织化学法检测70例骨肉瘤患者和20例骨软骨瘤患者手术切除组织中S100A4和Snail表达水平.结果 S100A4骨肉瘤组织的阳性表达率为71.43％(50/70),明显高于骨软骨瘤组织阳性表达率[15.00％ (3/20)],两者差异有统计学意义(P＜0.01),Snail骨肉瘤组织的阳性表达率[80.00％(56/70)],明显高于骨软骨瘤组织的阳性表达率[10.00％(2/20)],两者差异有统计学意义(P＜0.01).S100A4和Snail表达水平均与骨肉瘤软组织浸润、临床分期、肺转移密切相关(P＜0.05).结论对骨肉瘤进行S100A4和Snail检测有助于判断肿瘤的侵袭和转移.
목적 탐토골육류조직중개결합단백S100A4화자지전록인자Snail적표체급의의.방법 응용면역조직화학법검측70례골육류환자화20례골연골류환자수술절제조직중S100A4화Snail표체수평.결과 S100A4골육류조직적양성표체솔위71.43％(50/70),명현고우골연골류조직양성표체솔[15.00％ (3/20)],량자차이유통계학의의(P＜0.01),Snail골육류조직적양성표체솔[80.00％(56/70)],명현고우골연골류조직적양성표체솔[10.00％(2/20)],량자차이유통계학의의(P＜0.01).S100A4화Snail표체수평균여골육류연조직침윤、림상분기、폐전이밀절상관(P＜0.05).결론 대골육류진행S100A4화Snail검측유조우판단종류적침습화전이.
Objective To study the expression of S100A4 and Snail in osteosarcoma and their clinical significances.Methods The expression levels of S100A4 and Snail in 70 cases of osteosarcoma tissues and 20 cases of osteochondroma tissues were detected by using immunohistochemical method.Restilts The positive expression rate of S100A4 was 71.43％ (50/70) in osteosarcoma tissues,and 15.00％ (3/20) in osteochondroma tissues (P ＜ 0.05),and that of Snail was 80.00％ (56/70) in Osteosarcoma tissues,and 10.00％ (2/20) in osteochondroma tissues (P＜ 0.01).The expression of S100A4 and Snail was related to soft tissue involvement,TNM stage and lung metastasis of osteosarcoma (P ＜ 0.05).Conclusion Detection of S100A4 and Snail expression in osteosarcoma helps to predict sarcoma invasion and metastasis.