中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2013年
7期
911-914
,共4页
白细胞介素8/血液%急性病%胰腺炎/诊断%Meta分析
白細胞介素8/血液%急性病%胰腺炎/診斷%Meta分析
백세포개소8/혈액%급성병%이선염/진단%Meta분석
Interleukin-8/blood%Acute disease%Pancreatitis/diagnosis%Meta-analysis
目的 采用系统评价Meta分析方法评价血清白介素-8(interleukin-8,IL-8)对重症急性胰腺炎(severe acute pancreatitis,SAP)的诊断价值.方法 计算机检索Pubmed、Embase、Cochrane图书馆、万方、CNKI、维普和CBM数据库,全面收集有关血清IL-8诊断SAP的相关临床研究,由两位研究者分别独立提取数据,采用STATA 9.2软件进行Meta分析.结果 根据纳入标准,5个诊断试验纳入本系统评价,共计299例SAP患者和2956例健康正常人.Meta分析结果表明:入院第1天,血清IL-8诊断SAP的敏感度、特异度、阳性预测值和阴性预测值分别为65.8％、66.5％、54.7和75.9；入院第2天,血清IL-8诊断SAP的敏感度、特异度、阳性预测值和阴性预测值分别为70.9％、91.3％、86.2和80.3；入院第1～2天血清IL-8诊断SAP的AUC分别为0.73(95％CI:0.21-0.97)和0.91(95％ CI:0.85-0.92)；入院第1～2天血清IL-8诊断SAP的DOR为6.1(95％ CI:2.8-13.2)和23.4(95％ CI:8.1-63.7).结论 入院第1—2天血清IL-8诊断SAP的准确性均较高,但入院第2天血清IL-8诊断效能优于第1天；血清IL-8对于SAP的早期诊断和病情预测具有重要的临床价值.
目的 採用繫統評價Meta分析方法評價血清白介素-8(interleukin-8,IL-8)對重癥急性胰腺炎(severe acute pancreatitis,SAP)的診斷價值.方法 計算機檢索Pubmed、Embase、Cochrane圖書館、萬方、CNKI、維普和CBM數據庫,全麵收集有關血清IL-8診斷SAP的相關臨床研究,由兩位研究者分彆獨立提取數據,採用STATA 9.2軟件進行Meta分析.結果 根據納入標準,5箇診斷試驗納入本繫統評價,共計299例SAP患者和2956例健康正常人.Meta分析結果錶明:入院第1天,血清IL-8診斷SAP的敏感度、特異度、暘性預測值和陰性預測值分彆為65.8％、66.5％、54.7和75.9；入院第2天,血清IL-8診斷SAP的敏感度、特異度、暘性預測值和陰性預測值分彆為70.9％、91.3％、86.2和80.3；入院第1～2天血清IL-8診斷SAP的AUC分彆為0.73(95％CI:0.21-0.97)和0.91(95％ CI:0.85-0.92)；入院第1～2天血清IL-8診斷SAP的DOR為6.1(95％ CI:2.8-13.2)和23.4(95％ CI:8.1-63.7).結論 入院第1—2天血清IL-8診斷SAP的準確性均較高,但入院第2天血清IL-8診斷效能優于第1天；血清IL-8對于SAP的早期診斷和病情預測具有重要的臨床價值.
목적 채용계통평개Meta분석방법평개혈청백개소-8(interleukin-8,IL-8)대중증급성이선염(severe acute pancreatitis,SAP)적진단개치.방법 계산궤검색Pubmed、Embase、Cochrane도서관、만방、CNKI、유보화CBM수거고,전면수집유관혈청IL-8진단SAP적상관림상연구,유량위연구자분별독립제취수거,채용STATA 9.2연건진행Meta분석.결과 근거납입표준,5개진단시험납입본계통평개,공계299례SAP환자화2956례건강정상인.Meta분석결과표명:입원제1천,혈청IL-8진단SAP적민감도、특이도、양성예측치화음성예측치분별위65.8％、66.5％、54.7화75.9；입원제2천,혈청IL-8진단SAP적민감도、특이도、양성예측치화음성예측치분별위70.9％、91.3％、86.2화80.3；입원제1～2천혈청IL-8진단SAP적AUC분별위0.73(95％CI:0.21-0.97)화0.91(95％ CI:0.85-0.92)；입원제1～2천혈청IL-8진단SAP적DOR위6.1(95％ CI:2.8-13.2)화23.4(95％ CI:8.1-63.7).결론 입원제1—2천혈청IL-8진단SAP적준학성균교고,단입원제2천혈청IL-8진단효능우우제1천；혈청IL-8대우SAP적조기진단화병정예측구유중요적림상개치.
Objective To investigate the diagnostic accuracy of serum interleukin-8 (IL-8) in predicting severe acute pancreatitis (SAP) by conducting a Meta-analysis.Methods Publications addressing the diagnostic accuracy of serum IL-8 in the diagnosis of SAP were selected from Pubmed,Embase,Cochrane library,CBM,Wanfang,VIP,and CNKI databases.Data analysis was conducted by STATA 9.2software.Results According to the inclusion criteria,five diagnosis tests were retrieved,including 299 SAP patients and 2956 healthy controls.Meta-analysis results showed that the pooled sensitivities of IL-8 were 65.8％and 70.9％ for days 1 and 2,respectively; the pooled specificities were 66.5％ and 91.3％ for days 1 and 2,respectively; the pooled positive predictive value were 54.7 and 86.2 for days 1 and 2,respectively; the pooled negative predictive value were 75.9 and 80.3 for days 1 and 2,respectively; the area under curve (AUC) were 0.73 (95％ CI:0.21-0.97) and 0.91 (95％ CI:0.85-0.92) for days 1 and 2,respectively; and the diagnostic odds ratio (DOR) were 6.1 (95％ CI:2.8-13.2) and 23.4(95 ％ CI:8.1-63.7) for days 1 and 2,respectively.Conclusions Serum IL-8 on day 1 and 2 seems to perform high accuracy in predicting SAP,but diagnosis accuracy of serum IL-8 on day 1 was superior than that on day 1.Serum IL-8 might be an important tool for early prediction and diagnosis of SAP.
