国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2013年
21期
3338-3342
,共5页
彭又生%陈伟彦%陈思颖%袁克敏
彭又生%陳偉彥%陳思穎%袁剋敏
팽우생%진위언%진사영%원극민
系统性红斑狼疮%α1-微球蛋白%N-乙酰-β-D-葡萄糖苷酶%β2-微球蛋白%转铁蛋白%微量白蛋白%免疫球蛋白G
繫統性紅斑狼瘡%α1-微毬蛋白%N-乙酰-β-D-葡萄糖苷酶%β2-微毬蛋白%轉鐵蛋白%微量白蛋白%免疫毬蛋白G
계통성홍반랑창%α1-미구단백%N-을선-β-D-포도당감매%β2-미구단백%전철단백%미량백단백%면역구단백G
Systemic lupus erythematosus%α1-microglobulin%N-acetyl-β-D-glucosamini dase enzyme%β2-microglobulin%Transferrin%Microalbumin%Immunoglobulin G
目的 探讨系统性红斑狼疮(systemic lupus erythematosus,SLE)患者尿微量蛋白的变化及临床意义.方法 选择52例SLE患者(SLE组)和40例健康志愿者(对照组),分别检测其尿常规(尿蛋白定性)和尿α1-微球蛋白(α 1-MG)、N-乙酰-β-D-葡萄糖苷酶(NAG)、β2-微球蛋白(β2-MG)、转铁蛋白(TRF)、微量白蛋白(MA)及免疫球蛋白G(IgG),同时检测血清肌酐(Cr)；并对检测结果和各指标的阳性检出率进行统计分析.结果 SLE组尿α1-MG、NAG、β 2-MG、TRF、MA和IgG显著升高,与对照组比较差异有统计学意义(P＜0.01).SLE组六项尿微量蛋白指标联合检测的阳性率明显高于血清Cr (P＜0.01).尿α1-MG、NAG和β 2-MG三项联合检测的阳性率明显高于尿TRF、MA和IgG三项联合检测(P＜0.05).单项指标的阳性检出率,尿IgG和尿TRF高于尿MA(P＜0.01,P＜0.05),尿α 1-MG和尿β 2-MG高于尿NAG(P＜0.01,P＜ 0.01).结论 SLE患者尿α 1-MG、NAG、β 2-MG、TRF、MA和IgG显著升高,适用于SLE患者肾功能损伤的早期诊断；SLE患者肾小管功能损伤的概率大于肾小球的功能损伤.在反映SLE患者肾小球功能损伤的指标中,尿IgG和尿TRF优于尿MA;在反映SLE患者肾小管功能损伤的指标中,尿β 2-MG和尿α1-MG优于尿NAG.
目的 探討繫統性紅斑狼瘡(systemic lupus erythematosus,SLE)患者尿微量蛋白的變化及臨床意義.方法 選擇52例SLE患者(SLE組)和40例健康誌願者(對照組),分彆檢測其尿常規(尿蛋白定性)和尿α1-微毬蛋白(α 1-MG)、N-乙酰-β-D-葡萄糖苷酶(NAG)、β2-微毬蛋白(β2-MG)、轉鐵蛋白(TRF)、微量白蛋白(MA)及免疫毬蛋白G(IgG),同時檢測血清肌酐(Cr)；併對檢測結果和各指標的暘性檢齣率進行統計分析.結果 SLE組尿α1-MG、NAG、β 2-MG、TRF、MA和IgG顯著升高,與對照組比較差異有統計學意義(P＜0.01).SLE組六項尿微量蛋白指標聯閤檢測的暘性率明顯高于血清Cr (P＜0.01).尿α1-MG、NAG和β 2-MG三項聯閤檢測的暘性率明顯高于尿TRF、MA和IgG三項聯閤檢測(P＜0.05).單項指標的暘性檢齣率,尿IgG和尿TRF高于尿MA(P＜0.01,P＜0.05),尿α 1-MG和尿β 2-MG高于尿NAG(P＜0.01,P＜ 0.01).結論 SLE患者尿α 1-MG、NAG、β 2-MG、TRF、MA和IgG顯著升高,適用于SLE患者腎功能損傷的早期診斷；SLE患者腎小管功能損傷的概率大于腎小毬的功能損傷.在反映SLE患者腎小毬功能損傷的指標中,尿IgG和尿TRF優于尿MA;在反映SLE患者腎小管功能損傷的指標中,尿β 2-MG和尿α1-MG優于尿NAG.
목적 탐토계통성홍반랑창(systemic lupus erythematosus,SLE)환자뇨미량단백적변화급림상의의.방법 선택52례SLE환자(SLE조)화40례건강지원자(대조조),분별검측기뇨상규(뇨단백정성)화뇨α1-미구단백(α 1-MG)、N-을선-β-D-포도당감매(NAG)、β2-미구단백(β2-MG)、전철단백(TRF)、미량백단백(MA)급면역구단백G(IgG),동시검측혈청기항(Cr)；병대검측결과화각지표적양성검출솔진행통계분석.결과 SLE조뇨α1-MG、NAG、β 2-MG、TRF、MA화IgG현저승고,여대조조비교차이유통계학의의(P＜0.01).SLE조륙항뇨미량단백지표연합검측적양성솔명현고우혈청Cr (P＜0.01).뇨α1-MG、NAG화β 2-MG삼항연합검측적양성솔명현고우뇨TRF、MA화IgG삼항연합검측(P＜0.05).단항지표적양성검출솔,뇨IgG화뇨TRF고우뇨MA(P＜0.01,P＜0.05),뇨α 1-MG화뇨β 2-MG고우뇨NAG(P＜0.01,P＜ 0.01).결론 SLE환자뇨α 1-MG、NAG、β 2-MG、TRF、MA화IgG현저승고,괄용우SLE환자신공능손상적조기진단；SLE환자신소관공능손상적개솔대우신소구적공능손상.재반영SLE환자신소구공능손상적지표중,뇨IgG화뇨TRF우우뇨MA;재반영SLE환자신소관공능손상적지표중,뇨β 2-MG화뇨α1-MG우우뇨NAG.
Objective To study the changes of urinary trace protein levels in patients with systemic lupus erythematosus(SLE) and its clinical significance.Methods The levels of urinary α 1-microglobulin (α 1-MG),β 2-microglohulin(β 2-MG),transferrin(TRF),microalbumin(MA),and immunoglobulin G(IgG)were detected by immunturbidimetry,N-acetyl-β-D-glucoseaminidase enzyme(NAG) was detected by biochemistry,and serum creatinine (Cr) was detected in 52 patients with SLE(SLE group) and 40 healthy volunteers(control group).The data was analyzed by IBM SPSS Statistics.Results The levels of ot 1-MG,NAG,β 2-MG,TRF,MA,and IgG were significantly higher in the SLE group than in the control group (P ＜ 0.01).The positive rate of combined detection of urinary trace proteins was higher than that of serum Cr (P ＜ 0.01).There was a statistical difference between the positive rate of combined detection of o 1-MG,NAG,and β 2-MG and the positive rate of combined detection of TRF,MA,and IgG in patients with SLE(P ＜ 0.05).The positive rates of IgG and TRF were higher than that of MA(P ＜ 0.05,P ＜ 0.05).The positive rates of β 2-MG and o 1-MG were higher than that of NAG(P ＜ 0.01,P ＜ 0.01).Conclusions Urinary o 1-MG,NAG,β 2-MG,TRF,MA,and IgG levels increase in patients with SLE and can be applied on early diagnosing the renal function injury of the patients with SLE.The patients with SLE are more likely to have renal tunnel function injury than to have renal glomerular function injury.Urinary IgG and urinary TRF are more sensitive than urinary MA in indicating the injury of renal glomerular function in patients with SLE.Urinary β 2-MG and urinary o 1-MG are more sensitive than urinary NAG in indicating the injury of renal tunnel function in patients with SLE.
