国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2014年
22期
3415-3418
,共4页
血管危险因素%轻度认知功能障碍%阿尔茨海默病
血管危險因素%輕度認知功能障礙%阿爾茨海默病
혈관위험인소%경도인지공능장애%아이자해묵병
Vascular risk factors%Mild cognitive impairment%Alzheimer's disease
目的 探讨血管危险因素与轻度认知功能障碍(Mild cognitive impairment,MCI)及阿尔茨海默病(Alzheimer'sdisease,AD)的关系,并进一步分析各因素与认知功能下降程度的相关性.方法 选择2012年6月至2014年6月于门诊及住院部诊断为MCI及AD的患者各35例,同期体检的性别、年龄、文化程度相匹配的健康老人35例为对照.所有研究对象均进行MMSE、ADAS-Cog量表评定,采集晨空腹血进行血脂、血糖检测,并分别记录性别、年龄、身高、体重、吸烟、饮酒等情况.采用最小显著性差异法(LSD)比较各组间血管危险因素的差异、Pearson's相关分析各因素与认知功能评分的相关性.结果 与对照组相比,MCI组、AD组体重指数、血胆固醇水平呈进行性下降,但仅AD组与对照组相比差异有统计学意义.收缩压水平MCI组、AD组与对照组相比均明显升高,MCI组与AD组比较差异亦有统计学意义.Pearson's分析可见各因素与认知功能下降程度之间呈线性相关.糖尿病、饮酒比率AD组与对照组相比亦明显升高.结论 血管危险因素在老年人认知功能下降过程中有重要的作用,并有可能指导AD早期诊断及治疗.
目的 探討血管危險因素與輕度認知功能障礙(Mild cognitive impairment,MCI)及阿爾茨海默病(Alzheimer'sdisease,AD)的關繫,併進一步分析各因素與認知功能下降程度的相關性.方法 選擇2012年6月至2014年6月于門診及住院部診斷為MCI及AD的患者各35例,同期體檢的性彆、年齡、文化程度相匹配的健康老人35例為對照.所有研究對象均進行MMSE、ADAS-Cog量錶評定,採集晨空腹血進行血脂、血糖檢測,併分彆記錄性彆、年齡、身高、體重、吸煙、飲酒等情況.採用最小顯著性差異法(LSD)比較各組間血管危險因素的差異、Pearson's相關分析各因素與認知功能評分的相關性.結果 與對照組相比,MCI組、AD組體重指數、血膽固醇水平呈進行性下降,但僅AD組與對照組相比差異有統計學意義.收縮壓水平MCI組、AD組與對照組相比均明顯升高,MCI組與AD組比較差異亦有統計學意義.Pearson's分析可見各因素與認知功能下降程度之間呈線性相關.糖尿病、飲酒比率AD組與對照組相比亦明顯升高.結論 血管危險因素在老年人認知功能下降過程中有重要的作用,併有可能指導AD早期診斷及治療.
목적 탐토혈관위험인소여경도인지공능장애(Mild cognitive impairment,MCI)급아이자해묵병(Alzheimer'sdisease,AD)적관계,병진일보분석각인소여인지공능하강정도적상관성.방법 선택2012년6월지2014년6월우문진급주원부진단위MCI급AD적환자각35례,동기체검적성별、년령、문화정도상필배적건강노인35례위대조.소유연구대상균진행MMSE、ADAS-Cog량표평정,채집신공복혈진행혈지、혈당검측,병분별기록성별、년령、신고、체중、흡연、음주등정황.채용최소현저성차이법(LSD)비교각조간혈관위험인소적차이、Pearson's상관분석각인소여인지공능평분적상관성.결과 여대조조상비,MCI조、AD조체중지수、혈담고순수평정진행성하강,단부AD조여대조조상비차이유통계학의의.수축압수평MCI조、AD조여대조조상비균명현승고,MCI조여AD조비교차이역유통계학의의.Pearson's분석가견각인소여인지공능하강정도지간정선성상관.당뇨병、음주비솔AD조여대조조상비역명현승고.결론 혈관위험인소재노년인인지공능하강과정중유중요적작용,병유가능지도AD조기진단급치료.
Objective To investigate the vascular risk factors in patients with mild cognitive impairment (MCI) and Alzheimer' s disease (AD) and then to analyze the correlation between the risk factors and the degree of cognitive decline.Methods The neurological functions of 35 healthy patients and 35 MCI and 35 AD patients were evaluated by neuropsychological examinations.The body mass index,total cholesterol,hypertension,history of smoking,alcohol consumption,and diabetes mellitus in all patients were evaluated.LSD was used to differentiate vascular risk factors between the 3 groups,and Pearson's correlation to study the correlations between the various factors and cognitive function score.Results In comparison with with the control group,the body mass index and cholesterol levels progressively decreased in the MCI group and the AD group,with statistical differences between the control group and the AD group.The systolic blood pressure increased more in the MCI group and the AD group than in the control group,with a statistical difference between the control group and the AD group.Pearson's correlation showed that vascular risk factors linearly correlated with the degree of cognitive dicline.Diabetes and alcohol drinking ratios were obviously higher in the AD group than in the control group.Conclusions Vascular risk factors play important roles the cognitive decline in the elderly and may direct the early diagnosis and treatment of AD.
