婴儿,新生儿%感染%降钙素基因相关肽
嬰兒,新生兒%感染%降鈣素基因相關肽
영인,신생인%감염%강개소기인상관태
Infan,Newborn%Infecfion%Calcitiouin Gene-Relaaledpep tide
目的 探讨血清降钙素原(PCT)检测在新生儿感染性疾病早期诊断的临床应用价值.方法 疑似感染患儿50例,入院时、入院第5天检测血清PCT、CRP值、血常规、血培养.并根据临床表现和检验结果将50例患儿分别分为细菌感染组32例和非细菌感染组18例,并进行PCT、CRP、血常规、血培养值比较.结果 细菌感染组入院时血清PCT值≥2μg/L 27例,WBC升高6例,CRP阳性7例,血培养(3 d)阳性4例,非细菌感染组入院时血清PCT值≥2 μg/L 2例、WBC升高2例,CRP阳性3例,血培养(3 d)阳性1例；入院第5天细菌感染组血清PCT值≥2 μg/L 23例、WBC升高15例,CRP阳性6例,血培养(5 d)阳性9例,非细菌感染组入院时血清PCT值≥2μg/L 1例、WBC升高3例,CRP阳性4例,血培养(5 d)阳性1例.两组入院时WBC,CRP,血培养阳性例数比较,X2值分别是0.50,0.19,0.62,均P＞0.05,差异无统计学意义,但PCT值:x2=25.30,P＜0.05,差异有统计学意义.入院第五天两组CRP阳性例数比较:x2=0.83,P＞0.05,差异无统计学意义,但PCT,WBC,血培养比较:x2 =20.30、4.39、8.56,均P＜0.05,差异有统计学意义.结论 血清PCT检测可作为新生儿早期感染的重要诊断指标,其敏感度和特异度均优于,血常规及血培养.
目的 探討血清降鈣素原(PCT)檢測在新生兒感染性疾病早期診斷的臨床應用價值.方法 疑似感染患兒50例,入院時、入院第5天檢測血清PCT、CRP值、血常規、血培養.併根據臨床錶現和檢驗結果將50例患兒分彆分為細菌感染組32例和非細菌感染組18例,併進行PCT、CRP、血常規、血培養值比較.結果 細菌感染組入院時血清PCT值≥2μg/L 27例,WBC升高6例,CRP暘性7例,血培養(3 d)暘性4例,非細菌感染組入院時血清PCT值≥2 μg/L 2例、WBC升高2例,CRP暘性3例,血培養(3 d)暘性1例；入院第5天細菌感染組血清PCT值≥2 μg/L 23例、WBC升高15例,CRP暘性6例,血培養(5 d)暘性9例,非細菌感染組入院時血清PCT值≥2μg/L 1例、WBC升高3例,CRP暘性4例,血培養(5 d)暘性1例.兩組入院時WBC,CRP,血培養暘性例數比較,X2值分彆是0.50,0.19,0.62,均P＞0.05,差異無統計學意義,但PCT值:x2=25.30,P＜0.05,差異有統計學意義.入院第五天兩組CRP暘性例數比較:x2=0.83,P＞0.05,差異無統計學意義,但PCT,WBC,血培養比較:x2 =20.30、4.39、8.56,均P＜0.05,差異有統計學意義.結論 血清PCT檢測可作為新生兒早期感染的重要診斷指標,其敏感度和特異度均優于,血常規及血培養.
목적 탐토혈청강개소원(PCT)검측재신생인감염성질병조기진단적림상응용개치.방법 의사감염환인50례,입원시、입원제5천검측혈청PCT、CRP치、혈상규、혈배양.병근거림상표현화검험결과장50례환인분별분위세균감염조32례화비세균감염조18례,병진행PCT、CRP、혈상규、혈배양치비교.결과 세균감염조입원시혈청PCT치≥2μg/L 27례,WBC승고6례,CRP양성7례,혈배양(3 d)양성4례,비세균감염조입원시혈청PCT치≥2 μg/L 2례、WBC승고2례,CRP양성3례,혈배양(3 d)양성1례；입원제5천세균감염조혈청PCT치≥2 μg/L 23례、WBC승고15례,CRP양성6례,혈배양(5 d)양성9례,비세균감염조입원시혈청PCT치≥2μg/L 1례、WBC승고3례,CRP양성4례,혈배양(5 d)양성1례.량조입원시WBC,CRP,혈배양양성례수비교,X2치분별시0.50,0.19,0.62,균P＞0.05,차이무통계학의의,단PCT치:x2=25.30,P＜0.05,차이유통계학의의.입원제오천량조CRP양성례수비교:x2=0.83,P＞0.05,차이무통계학의의,단PCT,WBC,혈배양비교:x2 =20.30、4.39、8.56,균P＜0.05,차이유통계학의의.결론 혈청PCT검측가작위신생인조기감염적중요진단지표,기민감도화특이도균우우,혈상규급혈배양.
Objective To explore the clinical application value of serum procalcitonin (PCT) detection in diagnosis of neonatal infection disease.Methods The serum PCT,CRP values,routine blood test,blood cultures of 50 children with suspected infection was detected at admission and five days after admission.According to the clinical manifestations and the test results,50 children were divided into the bacterial infection group (32 cases) of and non-bacterial infection group (18 cases),and the value of PCT,CRP,routine blood test,blood culture was compared.Results Of bacterial infection group at admission,the serum PCT values in 27 cases were more than or equal with 2μg/L,white blood cell (WBC) increased in 6 cases,CRP of 7 cases were positive,blood cultures (3d) of 4 cases were positive,and of non-bacterial infection group at admission,the serum PCT value in 2 cases were more than or equal with 2μg/L,WBC increased in 2 cases,blood cultures (3d) of 1 case was positive ; Of bacterial infection group 5 days after admission,the serum PCT value in 23 cases were more than or equal with 2μg/L,WBC increased in 15 cases,CRP of 6 cases were positive,blood culture (5d) of 9 case were positive,and of non-bacterial infection group 5 days after admission,the serum PCT value in 1 cases was more than or equal with 2μg/L,WBC increased in 3 cases,CRP of 4 cases were positive,blood culture (5d) of 1 case was positive.At admission the cases of WBC increasing,CRP positive,blood culture positive of the two groups had no statistically significant differences (x2 =0.50,0.19,0.62,all P ＞ 0.05),but the cases of the PCT value which was more than or equal with 2μg/L had statistically significant differences between the two groups (x2 =25.30,P ＜ 0.05).5 days after admission the cases of WBC increasing,PCT,blood culture positive of the two groups had no statistically significant differences (x2 =4.39,20.30,8.56,all P ＜ 0.05),but the cases of the CRP value significant differences between the two groups (x2 =0.83,P ＞ 0.05).Conclusion The detection of serum PCT can be used as an important index of diagnosis for early neonatal infections,and its sensitivity and specificity are better than,blood routine and blood culture.
