CAJ | 학술논문

高血糖是糖尿病肾病发病的重要原因之一.二肽基肽酶-4(DPP-4)抑制剂可减少胰高血糖素样肽-1(GLP-1)降解,改善机体高血糖状态,从而延缓糖尿病肾病病程的进展.此外,DPP-4抑制剂还可影响其他与糖尿病肾病相关的非GLP-1底物,如基质细胞衍生因子-1α、脑钠尿肽及金属内肽酶的表达,继而发挥GLP-1非依赖性的肾脏保护作用.研究DPP-4抑制剂对糖尿病患者肾脏的保护作用及其机制,将为其在糖尿病肾病治疗中的应用提供新的认识.
고혈당시당뇨병신병발병적중요원인지일.이태기태매-4(DPP-4)억제제가감소이고혈당소양태-1(GLP-1)강해,개선궤체고혈당상태,종이연완당뇨병신병병정적진전.차외,DPP-4억제제환가영향기타여당뇨병신병상관적비GLP-1저물,여기질세포연생인자-1α、뇌납뇨태급금속내태매적표체,계이발휘GLP-1비의뢰성적신장보호작용.연구DPP-4억제제대당뇨병환자신장적보호작용급기궤제,장위기재당뇨병신병치료중적응용제공신적인식.
Hyperglycemia is the most important risk factors of diabetic nephropathy.Dipeptidyl peptidase-Ⅳ (DPP-4) inhibitors can improve hyperglycemia via reduction of glucagon-like peptide-1 (GLP-1)degradation,thereby protecting against the development and progression of diabetic nephropathy.Furthermore,DPP-4 inhibitors have renal protective effect independent of GLP-1 through influencing the expression of other DPP-4 substrates,for example,stromal cell-derived factor-1α,brain natriuretic peptide and metal endopeptidase,which are related to the progression of diabetic nephropathy.Further study of renal protective effect of DPP-4 inhibitors in diabetic patients and the relevant mechanism,may provide new insights of the treatment in diabetic nephropathy with DPP-4 inhibitors.