CAJ | 학술논문

近年来文献相继报道肠促胰素除对糖代谢产生作用外,在骨代谢方面也产生重要作用,主要表现在促进骨形成、抑制骨吸收.其机制尚不明确,可能是通过影响骨钙素基因表达、骨保护素/核因子-κB受体活化因子配体系统和骨硬化蛋白水平.此外,肠促胰素对晚期糖基化终末产物、胰岛素、胰岛素样生长因子、降钙素及血脂的作用也可能影响骨代谢.
근년래문헌상계보도장촉이소제대당대사산생작용외,재골대사방면야산생중요작용,주요표현재촉진골형성、억제골흡수.기궤제상불명학,가능시통과영향골개소기인표체、골보호소/핵인자-κB수체활화인자배체계통화골경화단백수평.차외,장촉이소대만기당기화종말산물、이도소、이도소양생장인자、강개소급혈지적작용야가능영향골대사.
Literatures have been reported in recent years that incretin plays an important role in bone metabolism,mainly in promoting bone formation and inhibiting bone resorption,in addition to its effects on glucose metabolism.The mechanism is not clear,may be by affecting the expression of osteocalcin,osteoprotegerin/receptor activator of nuclear factor kappa-B ligand system and level of sclerosin.In addition,the action of incretin on advanced glycation end products,insulin,insulin-like growth factor,calcitonin and blood lipids may also affect bone metabolism.