CAJ | 학술논문

目的研究血清肝酶水平与2型糖尿病(T2DM)发病的相关性.方法选取郑州市社区调查的8 779人,检测受试者血清ALT、AST、γ-谷氨酰转移酶(GGT)以及TC、TG及血糖等相关生化指标.根据肝酶四分位水平分别分为第1～4四分位数组(Q1 ～Q4).Logistic回归分析Q2～Q4组相对Q1组发生T2DM的风险.用ROC曲线分析肝酶水平升高对T2DM的预测价值.结果Logistic回归分析显示,GGT的Q4水平相对Q1水平发生T2DM的风险(OR和95％ CI)为:男性4.043(2.759～5.924),女性4.239(3.172 ～5.664),高于ALT.ROC曲线分析相关因素对T2DM的预测价值,GGT曲线下面积(男性:0.63,女性:0.68)大于ALT、AST,且大于BMI、腰围和TG.结论血清GGT水平较血ALT、AST水平与T2DM发病的相关性更强,即使生理范围内水平的升高也是T2DM发病的危险因素.
목적 연구혈청간매수평여2형당뇨병(T2DM)발병적상관성.방법 선취정주시사구조사적8 779인,검측수시자혈청ALT、AST、γ-곡안선전이매(GGT)이급TC、TG급혈당등상관생화지표.근거간매사분위수평분별분위제1～4사분위수조(Q1 ～Q4).Logistic회귀분석Q2～Q4조상대Q1조발생T2DM적풍험.용ROC곡선분석간매수평승고대T2DM적예측개치.결과Logistic회귀분석현시,GGT적Q4수평상대Q1수평발생T2DM적풍험(OR화95％ CI)위:남성4.043(2.759～5.924),녀성4.239(3.172 ～5.664),고우ALT.ROC곡선분석상관인소대T2DM적예측개치,GGT곡선하면적(남성:0.63,녀성:0.68)대우ALT、AST,차대우BMI、요위화TG.결론혈청GGT수평교혈ALT、AST수평여T2DM발병적상관성경강,즉사생리범위내수평적승고야시T2DM발병적위험인소.
Objective To investigate the correlation between serum liver enzymes and onset of type 2 diabetes mellitus (T2DM).Methods A total of 8 779 individuals subjected to a Zhengzhou community survey were enrolled in the study and were tested for the following serum biochemical parameters,including ALT,AST,γ-glutamyl transferase (GGT),TC,TG and blood glucose.All subjects were divided into four groups (Q1-Q4) according to the quartiles of their liver enzyme levels.Logistic regression was performed to explore the odd ratio (OR) for the onset of T2DM in groups of Q2-Q4 compared with the group of Q1.ROC curve was used to analyze the predictive value of elevated liver enzymes for the onset of T2DM.Results When the quartiles were defined by the GGT level,compared with the group of Q1,the OR for the group of Q4 was 4.043 (95 ％ CI 2.759-5.924) in the male and 4.239 (95 ％ CI 3.172-5.664) in the female,which was higher than the OR when the quartiles were defined by the ALT level.In the ROC curve,the AUC of GGT was larger than those of ALT,AST,BMI,waist circumference and TG,with 0.63 for the male and 0.68 for the female.Conclusions Serum level of GGT is more closely correlated with the onset of T2MD than the level of ALT or AST.Even the increase of serum GGT within physiological range is a risk factor for the onset of T2DM.