CAJ | 학술논문

硫化氢（hydrogen sulfide，H2S）作为新型的气体信号分子，广泛参与人体各个系统的调节。已知它在心血管系统、神经系统以及胃肠道系统中具有重要的调节作用。本文对近年来H2S在体内合成与代谢、生理活性、检测手段以及相关药物研发做一综述，为H2S供体型药物的研发与临床治疗提供有价值的参考。
류화경（hydrogen sulfide，H2S）작위신형적기체신호분자，엄범삼여인체각개계통적조절。이지타재심혈관계통、신경계통이급위장도계통중구유중요적조절작용。본문대근년래H2S재체내합성여대사、생리활성、검측수단이급상관약물연발주일종술，위H2S공체형약물적연발여림상치료제공유개치적삼고。
Apart from nitric oxide (NO) and carbon monoxide (CO), hydrogen sulfide (H2S) has been considered as the third endogenous signaling gasotransmitter. The past few years have elucidated its signifi-cant role in cardiovascular system, nervous system and gastrointestinal system. In this review, we will sum-marize enzymatic pathways of H2S production and metabolism, overview its main biological activities, and outline fluorescent probes used for detecting H2S. Some H2S-donating drugs will also be involved to provide information for relevant new drug development.